Fundamental principles of molecular recognition, physiochemical properties of drugs, drug metabolism and disposition, interaction of molecules with DNA/RNA. prereq: Med chem grad student or instr consent

Fundamental principles of molecular recognition, physicochemical properties of drugs, drug metabolism and disposition, interaction of molecules with DNA/RNA. prereq: Med chem grad student or instr consent

Didactic instruction in foundational principles of physical and mechanistic organic chemistry. Recitation component in which students actively solve organic chemistry reaction mechanisms and related problems in organic and medicinal chemistry during course meeting times with faculty guidance. prereq: First-year Medicinal Chemistry grad students or by permission.

Emphasis is an intro to bioassay & rodent experimental design approaches, data analysis & basic statistical analysis of corresponding data. Concepts of what instrumentation resources are available within the Department of Medicinal Chemistry & the Institute for Therapeutics Discovery & Development (ITDD), what the corresponding bioassays that can be measured on those resources, considerations & criteria for the development of a new bioassay, how to design basic rodent (mouse & rat) animal experiments including power-analysis (how to predict the number of animals needed for the experiment), as well as data analysis [mean, standard error of the mean (SEM), standard deviation of the mean (SD)] & statistical analysis [student t-test, one-way Anova, two-way Anova, & appropriate post-hoc tests). prereq: MEDC 8001 or instructor permission.

Core course; fundamental concepts, reactions, reagents, structural and stereochemical issues, and mechanistic skills necessary for understanding organic chemistry. prereq: 2302 or equiv

Builds sensitivity to ethical issues in chemical research. Readings/case studies, small-group/large-group discussion, summarizing comments from instructors/guests/panels having special expertise. Weekly seminar. prereq: Chem grad student

Protein structure, methods to determine structure, protein folding, forces stabilizing macromolecular structure, protein engineering, design. Dynamic properties of proteins/enzymes, enzyme substrate complexes, mechanism of enzyme catalysis.

Enzymology of metabolism, metabolic regulation, metabolic control and cell signaling.

Theory and practice in the determination of three-dimensional structures of macromolecules using x-ray and neutron diffraction and electron microscopy. prereq: (Introductory biochemistry, introductory physics, college calculus] or physical chemistry or instr consent

Biochemical dynamics from perspectives of kinetics and spectroscopy. Influence of structure, molecular interactions, and chemical transformations on biochemical reactions. Focuses on computational, spectroscopic, and physical methods. Steady-state and transient kinetics. Optical and magnetic resonance spectroscopies. prereq: Intro physical chemistry or equiv; intro biochemistry recommended

This course introduces graduate students to fundamental concepts of Biochemical Unity (Part 1) and Cell Theory (Part 2). For Part 1, we will discuss matter of life, equilibrium, entropy & law of mass action, two state systems, random walks & diffusion, rate equations of chemical reactions, and explore how they relate to regulation of biological networks (gene regulation and signal transduction). For Part 2 we will focus on properties of biological membranes, membrane trafficking, protein import & degradation, nuclear structures and their function, as well as molecular motors, cytoskeletal dynamics, and mitosis. The course assumes students have had previous undergraduate courses in cell biology, biochemistry and genetics. prereq: [[[4034 or 8121 or BioC 8002], Biol 4004] or BMBB or MCDBG grad student] or instr consent

Chemistry of amino acids, peptides, proteins, lipids, carbohydrates, and nucleic acids. Structure, nomenclature, synthesis, and reactivity. Overview of techniques used to characterize these biomolecules. prereq: 2302 or equiv

Molecular simulation for students in medicinal chemistry, pharmaceutics, biochemistry, and chemical physics prereq: Chem 3502 or instr consent

Quantitative methods (HPLC, GC, TLC, immunoassays) for analysis of drugs/metabolites in biological fluids. Advanced techniques such as capillary electrophoresis, supercritical fluid chromatography, GC-MS, LC-MS, tandem mass spectrometry. Chromatographic theory/statistical approaches to method validation.

The objectives of this course are to provide a comprehensive overview of antimicrobial agents used in infectious diseases with an emphasis on the underlying foundational principles in chemistry and biology. Antibiotic, antifungal, and antiprotozoal agents will be covered. For each antimicrobial agent, the history, discovery, synthesis, structure-activity relationships, spectrum of activity, clinical uses, mechanism(s) of action, resistance, drug disposition properties, and adverse reactions will be discussed in great detail.

Biosynthesis of natural products with an emphasis on how these biochemical principles can be used in drug discovery and design through metabolic engineering and combinatorial biosynthesis. Natural product isolation, structure determination, target identification, and the role of synthetic organic chemistry. prereq: [CHEM 8321, biochemistry] or equiv or course director approval

Combinatorial chemistry, multi-compound based technologies, their use in screening bioassays to discover lead compounds. Solidphase synthesis, designing compound libraries, pharmacological assay design, data interpretation, biological target selection, compound lead optimization. prereq: Undergraduate [chemistry or biochemistry] or instr consent

Chemical aspects of nucleic acid structure and function, synthesis, and functional variants. prereq: [Medicinal chem or chem or biochem] grad student

Cancer Drug Therapy is a relatively new field of medicine that has undergone many medical and societal changes over the course of the last 100 years and in particular the last 60 years. The emphasis in this course will be to familiarize the student with the basic concepts of cancer biology and to survey current advanced approaches for the development and design of small molecule, protein and cell based therapeutics for the treatment of cancer.

Current approaches to rational design of drugs. prereq: 5600 or instr consent

Structure of biological macromolecules that are targets of drugs. Techniques to accelerate directed drug discovery. Protein structure/interactions. Popular target classes. Computational tools for visualizing/analyzing protein-ligand and protein-protein interactions. Structural characterization at a level sufficient to underpin critical data evaluation. Biophysical techniques to assess weak ligand binding and suitable for fragment-based lead discovery. prereq: 5710 or 8002 or CHEM 5412 or structural biochemistry or instr consent

Modern studies. Topics, which vary by year, include natural products, heterocycles, asymmetric synthesis, organometallic chemistry, and polymer chemistry. prereq: 2302 or equiv

Students will acquire fundamental knowledge of the mechanisms of action, risks, and potential effects of the major CBRNE (chemical, biological, radiological, nuclear, and high explosive) agents that pose a threat in terrorist attacks. Students will also develop familiarity with current countermeasures (pre- and post-exposure) and relevant medical treatments, focusing on effectiveness, limitations, unmet needs, challenges, and roadblocks to countermeasure development. Detection, protection, and decontamination techniques will also be discussed. This course is designed for scientists and engineers: graduate students in Medicinal Chemistry, Chemistry, Biochemistry, Chemical Engineering, Biomedical Engineering, or Physics. Advanced undergraduates in the above programs, and professional students in PharmD, MD, MD/PhD, DVM, or MPH programs, who meet all required prerequisites, may enroll with the course director?s permission. Note that the emphasis of this course is on the chemistry, biology, and physics of CBRNE agents and their countermeasures, not policy, policymaking, or sociocultural issues (although these may come up for discussion).

(No description) prereq: Max 18 cr per semester or summer; 10 cr total required [Plan A only]