Twin Cities campus
 
Twin Cities Campus

Medicinal Chemistry M.S.

Graduate Studies in Medicinal Chemistry
College of Pharmacy
Link to a list of faculty for this program.
Contact Information
Department of Medicinal Chemistry, 8-101 Weaver-Densford Hall, 308 Harvard Street SE, Minneapolis, MN 55455 (612-624-9919; fax: 612-626-3114)
  • Program Type: Master's
  • Requirements for this program are current for Fall 2017
  • Length of program in credits: 30
  • This program does not require summer semesters for timely completion.
  • Degree: Master of Science
Along with the program-specific requirements listed below, please read the General Information section of this website for requirements that apply to all major fields.
Note: Students are not admitted directly to the MS program. See the Medicinal Chemistry PhD or contact the director of graduate studies for more information. The medicinal chemistry program emphasizes the application of chemical principles to research on the action of drugs on biological systems. Courses offered by the program focus on general principles of medicinal chemistry, drug design and synthesis, chemical aspects of drug metabolism, chemical mechanisms of drug toxicity and carcinogenicity, computer-assisted drug design and receptor modeling, and combinatorial chemistry. Students must complete a core curriculum of advanced courses in organic and medicinal chemistry, as well as credits in a minor or related field.
Program Delivery
  • via classroom (the majority of instruction is face-to-face)
Prerequisites for Admission
Special Application Requirements:
Note: Students are not admitted directly to the M.S. program. See the Medicinal Chemistry Ph.D.
For an online application or for more information about graduate education admissions, see the General Information section of this website.
Program Requirements
Plan A: Plan A requires 14 major credits, 6 credits outside the major, and 10 thesis credits. The final exam is oral.
This program may be completed with a minor.
Use of 4xxx courses toward program requirements is permitted under certain conditions with adviser approval.
A minimum GPA of 3.00 is required for students to remain in good standing.
At least 2 semesters must be completed before filing a Degree Program Form.
Students complete a 14-credit core curriculum of advanced courses in organic chemistry and medicinal chemistry. In addition, students take 6 credits of coursework, chosen in consultation with the advisor, which supports the course of study.
Required Courses
MEDC 8001 - General Principles of Medicinal Chemistry (3.0 cr)
MEDC 8002 - General Principles of Medicinal Chemistry (3.0 cr)
MEDC 8050 - Physical and Mechanistic Organic Chemistry (2.0 cr)
MEDC 8100 - Medicinal Chemistry Seminar (1.0 cr)
MEDC 8435 - BioAssay & Data Analysis (1.0 cr)
CHEM 8321 - Organic Synthesis (4.0 cr)
Additional Courses
Take at least 1 course from the following list. Choose remaining coursework to meet the 6-credit minimum in consultation with the advisor.
MEDC 5185 - Principles of Biomolecular Simulation (3.0 cr)
MEDC 5494 - Advanced Methods in Quantitative Drug Analysis (2.0 cr)
MEDC 8500 - Design of Chemotherapeutic Agents (2.0 cr)
MEDC 8753 - MOLECULAR TARGETS OF DRUG DISCOVERY (3.0 cr)
MEDC 8420 - Natural Products Chemistry (3.0 cr)
MEDC 8471 - High Throughput Drug Discovery (3.0 cr)
MEDC 8413 - Chemistry of Nucleic Acids (3.0 cr)
MEDC 8700 - Advanced Concepts in Drug Design (2.0 cr)
Thesis Credits
Take at least 10 masterís thesis credits.
MEDC 8777 - Thesis Credits: Master's (1.0-18.0 cr)
 
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MEDC 8001 - General Principles of Medicinal Chemistry
Credits: 3.0 [max 3.0]
Course Equivalencies: 01872
Grading Basis: A-F or Aud
Typically offered: Every Fall
Fundamental principles of molecular recognition, physiochemical properties of drugs, drug metabolism and disposition, interaction of molecules with DNA/RNA. prereq: Med chem grad student or instr consent
MEDC 8002 - General Principles of Medicinal Chemistry
Credits: 3.0 [max 3.0]
Course Equivalencies: 01889
Grading Basis: A-F or Aud
Typically offered: Every Spring
Fundamental principles of molecular recognition, physicochemical properties of drugs, drug metabolism and disposition, interaction of molecules with DNA/RNA. prereq: Med chem grad student or instr consent
MEDC 8050 - Physical and Mechanistic Organic Chemistry
Credits: 2.0 [max 2.0]
Prerequisites: First-year Medicinal Chemistry grad students or by permission.
Grading Basis: A-F only
Typically offered: Every Fall
Didactic instruction in foundational principles of physical and mechanistic organic chemistry. Recitation component in which students actively solve organic chemistry reaction mechanisms and related problems in organic and medicinal chemistry during course meeting times with faculty guidance. prereq: First-year Medicinal Chemistry grad students or by permission.
MEDC 8100 - Medicinal Chemistry Seminar
Credits: 1.0 [max 6.0]
Grading Basis: A-F only
Typically offered: Every Fall & Spring
Current topics. prereq: Grad major or instr consent
MEDC 8435 - BioAssay & Data Analysis
Credits: 1.0 [max 1.0]
Prerequisites: MEDC 8001 or instructor permission.
Grading Basis: A-F or Aud
Typically offered: Spring Even Year
Emphasis is an intro to bioassay & rodent experimental design approaches, data analysis & basic statistical analysis of corresponding data. Concepts of what instrumentation resources are available within the Department of Medicinal Chemistry & the Institute for Therapeutics Discovery & Development (ITDD), what the corresponding bioassays that can be measured on those resources, considerations & criteria for the development of a new bioassay, how to design basic rodent (mouse & rat) animal experiments including power-analysis (how to predict the number of animals needed for the experiment), as well as data analysis [mean, standard error of the mean (SEM), standard deviation of the mean (SD)] & statistical analysis [student t-test, one-way Anova, two-way Anova, & appropriate post-hoc tests). prereq: MEDC 8001 or instructor permission.
CHEM 8321 - Organic Synthesis
Credits: 4.0 [max 4.0]
Typically offered: Every Fall
Core course; fundamental concepts, reactions, reagents, structural and stereochemical issues, and mechanistic skills necessary for understanding organic chemistry. prereq: 2302 or equiv
MEDC 5185 - Principles of Biomolecular Simulation
Credits: 3.0 [max 3.0]
Typically offered: Periodic Fall
Molecular simulation for students in medicinal chemistry, pharmaceutics, biochemistry, and chemical physics prereq: Chem 3502 or instr consent
MEDC 5494 - Advanced Methods in Quantitative Drug Analysis
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Periodic Fall & Spring
Quantitative methods (HPLC, GC, TLC, immunoassays) for analysis of drugs/metabolites in biological fluids. Advanced techniques such as capillary electrophoresis, supercritical fluid chromatography, GC-MS, LC-MS, tandem mass spectrometry. Chromatographic theory/statistical approaches to method validation.
MEDC 8500 - Design of Chemotherapeutic Agents
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Periodic Fall
Modern aspects of designing chemotherapeutic agents. Strategies for enzyme inhibition and metabolic blocks in development of anticancer, antimicrobial, and antiviral agents. prereq: 5600 or instr consent
MEDC 8753 - MOLECULAR TARGETS OF DRUG DISCOVERY
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Fall Even Year
Structure of biological macromolecules that are targets of drugs. Techniques to accelerate directed drug discovery. Protein structure/interactions. Popular target classes. Computational tools for visualizing/analyzing protein-ligand and protein-protein interactions. Structural characterization at a level sufficient to underpin critical data evaluation. Biophysical techniques to assess weak ligand binding and suitable for fragment-based lead discovery. prereq: 5710 or 8002 or CHEM 5412 or structural biochemistry or instr consent
MEDC 8420 - Natural Products Chemistry
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Spring Odd Year
Biosynthesis of natural products with an emphasis on how these biochemical principles can be used in drug discovery and design through metabolic engineering and combinatorial biosynthesis. Natural product isolation, structure determination, target identification, and the role of synthetic organic chemistry. prereq: [CHEM 8321, biochemistry] or equiv or course director approval
MEDC 8471 - High Throughput Drug Discovery
Credits: 3.0 [max 3.0]
Prerequisites: Undergraduate [chemistry or biochemistry] or #
Grading Basis: A-F only
Typically offered: Spring Even Year
Combinatorial chemistry, multi-compound based technologies, their use in screening bioassays to discover lead compounds. Solidphase synthesis, designing compound libraries, pharmacological assay design, data interpretation, biological target selection, compound lead optimization. prereq: Undergraduate [chemistry or biochemistry] or instr consent
MEDC 8413 - Chemistry of Nucleic Acids
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Spring Even Year
Chemical aspects of nucleic acid structure and function, synthesis, and functional variants. prereq: [Medicinal chem or chem or biochem] grad student
MEDC 8700 - Advanced Concepts in Drug Design
Credits: 2.0 [max 2.0]
Course Equivalencies: Chem 8700/MedC 8700/Phar 6246H
Grading Basis: A-F or Aud
Typically offered: Periodic Spring
Current approaches to rational design of drugs. prereq: 5600 or instr consent
MEDC 8777 - Thesis Credits: Master's
Credits: 1.0 -18.0 [max 50.0]
Grading Basis: No Grade
Typically offered: Every Fall, Spring & Summer
(No description) prereq: Max 18 cr per semester or summer; 10 cr total required [Plan A only]