Twin Cities campus
 
Twin Cities Campus

Clinical Research M.S.

School of Public Health - Adm
School of Public Health
Link to a list of faculty for this program.
Contact Information
School of Public Health, MMC 819, A395 Mayo Memorial Building, 420 Delaware Street, Minneapolis, MN 55455 (612-626-3500 OR 1-800-774-8636)
  • Program Type: Master's
  • Requirements for this program are current for Spring 2020
  • Length of program in credits: 38
  • This program does not require summer semesters for timely completion.
  • Degree: Master of Science
Along with the program-specific requirements listed below, please read the General Information section of this website for requirements that apply to all major fields.
The MS in clinical research is a graduate degree as well as a career development path for physician-scientists, clinical scholars, and biomedical researchers. The program trains students to conduct patient-oriented research, directly interacting with human subjects to better understand disease, the development of therapeutic interventions, and the conduct of clinical trials. Students learn how to conduct epidemiologic and behavioral studies and understand issues related to outcomes-based research, and also develop grant writing and data analytic skills.
Program Delivery
  • partially online (between 50% to 80% of instruction is online)
Prerequisites for Admission
The preferred undergraduate GPA for admittance to the program is 3.00.
An advanced health professional degree (MD, DDS, DVM, DO, DNP, DC, PharmD, PhD, etc.) or other advanced doctoral degree in a clinical biomedical field from an accredited university.
Other requirements to be completed before admission:
Students must have completed or must be at an advanced stage of their clinical practice training and be affiliated with a University faculty member eligible to advise and access a clinical project. The admissions committee considers exceptions on an individual basis.
Special Application Requirements:
An official transcript verifying completion of an advanced health professional degree and training sufficient to be eligible for a license to practice. One of the three required recommendation letters and a completed School of Public Health Recommendation form from the clinical director of training supporting the applicant's potential as a clinical researcher.
International applicants must submit score(s) from one of the following tests:
  • TOEFL
    • Internet Based - Total Score: 100
    • Paper Based - Total Score: 600
  • IELTS
    • Total Score: 7.0
  • MELAB
    • Final score: 80
The preferred English language test is Test of English as Foreign Language.
Key to test abbreviations (TOEFL, IELTS, MELAB).
For an online application or for more information about graduate education admissions, see the General Information section of this website.
Program Requirements
Plan A: Plan A requires 26 major credits, 2 credits outside the major, and 10 thesis credits. The final exam is oral.
Plan B: Plan B requires 28 to 32 major credits and 6 to 10 credits outside the major. The final exam is oral. A capstone project is required.
Capstone Project:Students can opt to complete a manuscript or a grant proposal for their capstone project. The topic and scope of the project must be approved by the advisor and director of graduate studies.
This program may be completed with a minor.
Use of 4xxx courses towards program requirements is not permitted.
A minimum GPA of 3.00 is required for students to remain in good standing.
At least 1 semesters must be completed before filing a Degree Program Form.
Students must complete both sessions of the University's Responsible Conduct of Research course, validated by ORTTA. Students also must complete the NIH's online training, Protection of Human Research Subjects, validated by electronic certificate upon successful completion. Plan A students will complete these requirements as part of the Plan A curriculum. A grade of at least B- must be earned for required courses taken on the A/F grade basis. If PUBH 6320 is taken, a grade of at least A- must be earned.
Required Core Courses (16 credits)
All students take the following courses:
PUBH 6301 - Fundamentals of Clinical Research (3.0 cr)
PUBH 6450 - Biostatistics I (4.0 cr)
PUBH 6451 - Biostatistics II (4.0 cr)
PUBH 6742 - Ethics in Public Health: Research and Policy (1.0 cr)
PUBH 6250 - Foundations of Public Health (2.0 cr)
PUBH 6307 - Clinical Epidemiology (2.0 cr)
Epidemiology Course (3 credits)
Select one of the following courses in consultation with the director of graduate studies.
PUBH 6341 - Epidemiologic Methods I (3.0 cr)
or PUBH 6320 - Fundamentals of Epidemiology (3.0 cr)
Clinical Trials Course (3 credits)
Select one of the following courses in consultation with the director of graduate studies.
PUBH 7420 - Clinical Trials: Design, Implementation, and Analysis (3.0 cr)
or PUBH 7415 - Introduction to Clinical Trials (3.0 cr)
Plan Options
Plan A Requirements
The Plan A curriculum prepares the next generation of clinical researchers and principal investigators. It covers clinical trials, epidemiology, biostatistics, ethics, grant writing, and research methods. Students are trained to conduct patient-oriented, epidemiological, and behavioral research.
Plan A Coursework (4 credits)
Take the following courses:
PUBH 6303 - Clinical Research Project Seminar (2.0 cr)
PUBH 6348 - Writing Research Grants (2.0 cr)
Elective Coursework
Select at least two elective credits, in consultation with the director of graduate studies, to meet the Plan A minimum course credit requirement.
DENT 8100 - Topics in Advanced Periodontology: Literature Review (2.0 cr)
DENT 8120 - Advanced Principles and Techniques of Orofacial Pain Disorders (2.0 cr)
DENT 8121 - Current Literature in TMD and Orofacial Pain (1.0 cr)
ECP 5220 - Regulatory Issues in Drug Research (2.0 cr)
ECP 5620 - Drug Metabolism and Disposition (3.0 cr)
ECP 8100 - Seminar (1.0 cr)
MICA 8013 - Translational Cancer Research (2.0 cr)
NURS 5925 - Grant Writing and Critique (1.0 cr)
NURS 6102 - Family Health Theory (2.0 cr)
NURS 7202 - Moral and Ethical Positions and Actions in Nursing (2.0 cr)
NURS 8152 - Scholarship in Health Care Ethics (3.0 cr)
NURS 8172 - Theory and Theory Development for Research (3.0 cr)
NURS 8173 - Principles and Methods of Implementing Research (3.0 cr)
NURS 8175 - Quantitative Research Design and Methods (3.0 cr)
PHAR 6224 - Pharmacogenomics: Genetic Basis for Variability in Drug Response (2.0 cr)
PHCL 5111 - Pharmacogenomics (3.0 cr)
PUBH 6181 - Surveillance of Foodborne Diseases and Food Safety Hazards (2.0 cr)
PUBH 6325 - Data Processing with PC-SAS (1.0 cr)
PUBH 6343 - Epidemiologic Methods III (4.0 cr)
PUBH 6375 - Screening for Disease: a Double-Edged Sword? (2.0 cr)
PUBH 6381 - Genetics in Public Health in the Age of Precision Medicine (2.0 cr)
PUBH 6383 - Vaccines (2.0 cr)
PUBH 6385 - Epidemiology and Control of Infectious Diseases (2.0 cr)
PUBH 6386 - Cardiovascular Disease Epidemiology and Prevention (2.0 cr)
PUBH 6387 - Cancer Epidemiology (2.0 cr)
PUBH 6389 - Nutritional Epidemiology (2.0 cr)
PUBH 6420 - Introduction to SAS Programming (1.0 cr)
PUBH 6717 - Decision Analysis for Health Care (2.0 cr)
PUBH 6803 - Conducting a Systematic Literature Review (3.0 cr)
PUBH 6863 - Understanding Health Care Quality (2.0 cr)
PUBH 6864 - Conducting Health Outcomes Research (3.0 cr)
PUBH 7430 - Statistical Methods for Correlated Data (3.0 cr)
PUBH 7440 - Introduction to Bayesian Analysis (3.0 cr)
PUBH 7445 - Statistics for Human Genetics and Molecular Biology (3.0 cr)
PUBH 7450 - Survival Analysis (3.0 cr)
PUBH 7470 - Study Designs in Biomedical Research (3.0 cr)
TMDP 8441 - Seminar in Temporomandibular Disorders & Orofacial Pain (1.0 cr)
VMED 5080 - Problems in Veterinary Epidemiology and Public Health (1.0-3.0 cr)
VMED 5165 - Surveillance of Foodborne Diseases and Food Safety Hazards (2.0 cr)
VMED 8090 - Epidemiology of Zoonoses and Diseases Common to Animals and Humans (3.0 cr)
Thesis Credits
Take at least 10 master's thesis credits.
PUBH 8777 - Thesis Credits: Master's (1.0-18.0 cr)
-OR-
Plan B Requirements
The Plan B curriculum prepares the next generation of translational, clinical, and outcomes researchers. The flexible curriculum, determined through consultation with mentors and the director of graduate studies, includes a core of required courses covering clinical trials, epidemiology, and biostatistics, supplemented by elective courses in translational sciences, outcomes sciences, health services research, and other areas.
Elective Coursework
Select electives in consultation with the director of graduate studies to meet the 38-credit minimum.
DENT 8100 - Topics in Advanced Periodontology: Literature Review (2.0 cr)
DENT 8120 - Advanced Principles and Techniques of Orofacial Pain Disorders (2.0 cr)
DENT 8121 - Current Literature in TMD and Orofacial Pain (1.0 cr)
ECP 5220 - Regulatory Issues in Drug Research (2.0 cr)
ECP 5620 - Drug Metabolism and Disposition (3.0 cr)
ECP 8100 - Seminar (1.0 cr)
MICA 8013 - Translational Cancer Research (2.0 cr)
NURS 5925 - Grant Writing and Critique (1.0 cr)
NURS 6102 - Family Health Theory (2.0 cr)
NURS 7202 - Moral and Ethical Positions and Actions in Nursing (2.0 cr)
NURS 8152 - Scholarship in Health Care Ethics (3.0 cr)
NURS 8172 - Theory and Theory Development for Research (3.0 cr)
NURS 8173 - Principles and Methods of Implementing Research (3.0 cr)
NURS 8175 - Quantitative Research Design and Methods (3.0 cr)
PHAR 6224 - Pharmacogenomics: Genetic Basis for Variability in Drug Response (2.0 cr)
PHCL 5111 - Pharmacogenomics (3.0 cr)
PUBH 6181 - Surveillance of Foodborne Diseases and Food Safety Hazards (2.0 cr)
PUBH 6303 - Clinical Research Project Seminar (2.0 cr)
PUBH 6325 - Data Processing with PC-SAS (1.0 cr)
PUBH 6343 - Epidemiologic Methods III (4.0 cr)
PUBH 6348 - Writing Research Grants (2.0 cr)
PUBH 6375 - Screening for Disease: a Double-Edged Sword? (2.0 cr)
PUBH 6381 - Genetics in Public Health in the Age of Precision Medicine (2.0 cr)
PUBH 6383 - Vaccines (2.0 cr)
PUBH 6385 - Epidemiology and Control of Infectious Diseases (2.0 cr)
PUBH 6386 - Cardiovascular Disease Epidemiology and Prevention (2.0 cr)
PUBH 6387 - Cancer Epidemiology (2.0 cr)
PUBH 6389 - Nutritional Epidemiology (2.0 cr)
PUBH 6420 - Introduction to SAS Programming (1.0 cr)
PUBH 6717 - Decision Analysis for Health Care (2.0 cr)
PUBH 6803 - Conducting a Systematic Literature Review (3.0 cr)
PUBH 6863 - Understanding Health Care Quality (2.0 cr)
PUBH 6864 - Conducting Health Outcomes Research (3.0 cr)
PUBH 7430 - Statistical Methods for Correlated Data (3.0 cr)
PUBH 7440 - Introduction to Bayesian Analysis (3.0 cr)
PUBH 7445 - Statistics for Human Genetics and Molecular Biology (3.0 cr)
PUBH 7450 - Survival Analysis (3.0 cr)
PUBH 7470 - Study Designs in Biomedical Research (3.0 cr)
TMDP 8441 - Seminar in Temporomandibular Disorders & Orofacial Pain (1.0 cr)
VMED 5080 - Problems in Veterinary Epidemiology and Public Health (1.0-3.0 cr)
VMED 5165 - Surveillance of Foodborne Diseases and Food Safety Hazards (2.0 cr)
VMED 8090 - Epidemiology of Zoonoses and Diseases Common to Animals and Humans (3.0 cr)
Capstone Project
Take 6 to 10 credits of PUBH 8394, in consultation with the advisor and director of graduate studies.
PUBH 8394 - Plan B Project: Clinical Research (1.0-10.0 cr)
 
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PUBH 6301 - Fundamentals of Clinical Research
Credits: 3.0 [max 3.0]
Course Equivalencies: 00562
Typically offered: Every Fall
Concepts of clinical research design/implementation/analysis. Students will learn skills needed for research in humans.
PUBH 6450 - Biostatistics I
Credits: 4.0 [max 4.0]
Grading Basis: A-F only
Typically offered: Every Fall & Spring
Descriptive statistics. Gaussian probability models, point/interval estimation for means/proportions. Hypothesis testing, including t, chi-square, and nonparametric tests. Simple regression/correlation. ANOVA. Health science applications using output from statistical packages. prereq: [College-level algebra, health sciences grad student] or instr consent
PUBH 6451 - Biostatistics II
Credits: 4.0 [max 4.0]
Typically offered: Every Fall & Spring
Two-way ANOVA, interactions, repeated measures, general linear models. Logistic regression for cohort and case-control studies. Loglinear models, contingency tables, Poisson regression, survival data, Kaplan-Meier methods, proportional hazards models. prereq: [PubH 6450 with grade of at least B, health sciences grad student] or instr consent
PUBH 6742 - Ethics in Public Health: Research and Policy
Credits: 1.0 [max 1.0]
Grading Basis: A-F only
Typically offered: Every Fall, Spring & Summer
Introduction to ethical issues in public health research/policy. Ethical analysis. Recognizing/analyzing moral issues.
PUBH 6250 - Foundations of Public Health
Credits: 2.0 [max 4.0]
Grading Basis: A-F only
Typically offered: Every Fall, Spring & Summer
In this course we will examine values, contexts, principles, and frameworks of public health. We will provide an introduction to public health, consider the history of public health, social/political determinants, impact of health disparities on race, class and gender, moral and legal foundations, public health structures, historical trauma and cultural competence, health and human rights, advocacy and health equity, communication and financing, and the future of public health in the 21st century. Grounded in theory and concepts, we will incorporate core competencies and skills for public health professionals and will focus on developing problem solving and decision-making skills through critical analysis, reflection, case studies, readings, and paper assignments.
PUBH 6307 - Clinical Epidemiology
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Clinical epidemiology is the science of using population methods to answer individual patient questions. This course in clinical epidemiology will cover the design of epidemiological studies and the analysis and interpretation of epidemiological data in order to answer clinical questions. A variety of study designs methods including cohort, case-control, and cross-sectional study designs will be used. In addition to disease and exposure, the course will cover concepts related to prognosis, diagnosis, treatment and prevention. The design and analysis of clinical trials is covered in-depth by other courses (e.g. PubH 7420 and 7415) and hence is not covered here. This course is intended for MS students majoring in clinical research. Others including medical students, students in various MS programs, MPH and PhD programs in the School of Public Health and other interested students are welcome to enroll as long as they meet the course requirements. If you have already studied advanced methods in epidemiology or biostatistics or completed Epi Methods II (PubH 6342) or more advanced courses, please do not take this 2-credit course since there will be redundant material. You may contact the instructor to discuss alternative options instead.
PUBH 6341 - Epidemiologic Methods I
Credits: 3.0 [max 3.0]
Course Equivalencies: 02236 - PubH 6320PubH /6341
Grading Basis: A-F only
Typically offered: Every Fall
Introduction to epidemiologic concepts and methods: (1) Study design (randomized trials and observational studies); (2) Measures of exposure-disease association; (3) Casual inference and bias; (4) Confounding and effect modification.
PUBH 6320 - Fundamentals of Epidemiology
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Fall, Spring & Summer
This course provides an understanding of basic methods and tools used by epidemiologists to study the health of populations.
PUBH 7420 - Clinical Trials: Design, Implementation, and Analysis
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Introduction to and methodology of randomized clinical trials. Design issues, sample size, operational details, interim monitoring, data analysis issues, overviews. prereq: 6451 or concurrent registration is required (or allowed) in 6451 or 7406 or instr consent
PUBH 7415 - Introduction to Clinical Trials
Credits: 3.0 [max 3.0]
Typically offered: Every Fall & Summer
Hypotheses/endpoints, choice of intervention/control, ethical considerations, blinding/randomization, data collection/monitoring, sample size, analysis, writing. Protocol development, group discussions. prereq: 6414 or 6450 or one semester graduate-level introductory biostatistics or statistics or instr consent
PUBH 6303 - Clinical Research Project Seminar
Credits: 2.0 [max 2.0]
Grading Basis: S-N only
Typically offered: Every Spring
Students will present their thesis and give and receive feedback. Students must have their project underway.
PUBH 6348 - Writing Research Grants
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
Focuses on NIH research grants. Mechanisms of grant writing: specific aims, hypotheses, innovation, background, approaches, evaluation analyses, principles of informed consent, budget development, and grant-review process.
DENT 8100 - Topics in Advanced Periodontology: Literature Review
Credits: 2.0 [max 2.0]
Typically offered: Every Fall, Spring & Summer
State-of-the-art information on a variety of topics concerning risk factors and therapeutic modalities for periodontal disease.
DENT 8120 - Advanced Principles and Techniques of Orofacial Pain Disorders
Credits: 2.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Interdisciplinary study of theory, principles, epidemiology, mechanisms associated with TMJ/craniofacial pain disorders. Basis for scientific understanding of diagnostic/management strategies. prereq: Participation in TMJ, orofacial pain advanced education program
DENT 8121 - Current Literature in TMD and Orofacial Pain
Credits: 1.0 [max 1.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall, Spring & Summer
Review of current literature/how it relates to past literature. Theories on pain, philosophies of management.
ECP 5220 - Regulatory Issues in Drug Research
Credits: 2.0 [max 2.0]
Typically offered: Every Fall
Regulatory issues encountered in conducting drug research trials. Performing different aspects of clinical trials. Lectures, readings, small group discussions, homework assignments. prereq: ECP grad student or Pharm.D. professional student or instr consent
ECP 5620 - Drug Metabolism and Disposition
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Spring Odd Year
Oxidatative/conjugative enzymes systems involved in human drug metabolism/disposition. Various in vitro models used to evaluate drug metabolism or chemical entity, pros/cons of each. Factors involved in conducting in vivo studies. Components used to predict in vivo drug disposition from in vivo studies. prereq: Grad student or instr consent
ECP 8100 - Seminar
Credits: 1.0 [max 8.0]
Typically offered: Every Fall & Spring
Selected topics in experimental/clinical pharmacology. prereq: ECP grad student or instr consent
MICA 8013 - Translational Cancer Research
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Clinical issues in cancer research. Discuss translational research projects as they pertain to a variety of cancers. prereq: 8004 or instr consent
NURS 5925 - Grant Writing and Critique
Credits: 1.0 [max 1.0]
Typically offered: Every Spring
Self-paced course. Online modular format. How to write/critique grants. Students select a research or program grant to critique, applying knowledge obtained through learning modules. prereq: Grad student or instr consent
NURS 6102 - Family Health Theory
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Fall
Emerging theory in family nursing science, related theories. Research on family systems for structuring systemic framework to examine clinical problems related to family health care. Applies family health theories to selected phenomena of interest to health care. prereq: 6200 or instr consent
NURS 7202 - Moral and Ethical Positions and Actions in Nursing
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall & Spring
Normative ethics and theoretical underpinnings for positions taken. Implications for subsequent action. Morally defensible positions on health-related issues, corresponding actions from perspective of nursing.
NURS 8152 - Scholarship in Health Care Ethics
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Fall
Analyze the underlying values in the concepts and discourses of health/disease. Evaluate ethical frameworks regarding their capability to address issues in health care. Analyze/discuss issues related to the responsible and ethical conduct of research. prereq: Doctoral student or instr consent
NURS 8172 - Theory and Theory Development for Research
Credits: 3.0 [max 3.0]
Typically offered: Periodic Fall & Spring
Paradigms in nursing/health, associated methods of scientific/scholarly inquiry. Inductive/deductive techniques for theory development Theory-testing using data obtained under controlled conditions. prereq: Doctoral student
NURS 8173 - Principles and Methods of Implementing Research
Credits: 3.0 [max 3.0]
Course Equivalencies: 01044 - Nurs 8173/SAPh 8173
Typically offered: Every Spring
Integrates scientific, statistical, and practical aspects of research. Inter-relationships among design, sample selections, subject access, human subjects requirements, instrument selection and evaluation, data management, analyses plans, grant writing, and research career issues. Field experiences required. prereq: 8114 or other 8xxx grad research methods course, 2 grad stat courses;
NURS 8175 - Quantitative Research Design and Methods
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
Designs for quantitative description and quasi-experimental/experimental evaluation of scientific problems across domain of nursing. Evaluation of logic of design/attribution of causality from health and social science perspectives. prereq: [PhD student in nursing, advanced applied statistics] or instr consent
PHAR 6224 - Pharmacogenomics: Genetic Basis for Variability in Drug Response
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Spring
Theory/practice of pharmacogenomics. Principles of human genetics/genomics. Applications to scientific education, problems in drug therapy optimization, patient care. prereq: At least 3rd year or later in healthcare or related program or equivalent experience or instr consent
PHCL 5111 - Pharmacogenomics
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Human genetic variation, its implications. Functional genomics, pharmacogenomics, toxicogenomics, proteomics. Interactive, discussion-based course. prereq: Grad student or instr consent Keywords: Pharmacology, Pharmacogenomics, Toxicogenomics, Proteomics, Genetics, Drug
PUBH 6181 - Surveillance of Foodborne Diseases and Food Safety Hazards
Credits: 2.0 [max 2.0]
Course Equivalencies: PubH 5181/VMed 5165
Typically offered: Every Fall
Principles/methods for surveillance of foodborne diseases. Investigation of outbreaks, assessment of food safety hazards. Focuses on integration of epidemiologic/lab methods.
PUBH 6325 - Data Processing with PC-SAS
Credits: 1.0 [max 1.0]
Typically offered: Every Spring
Introduction to methods for transferring/processing existing data sources. Emphasizes hands-on approach to pre-statistical data processing and analysis with PC-SAS statistical software with a Microsoft Windows operating system.
PUBH 6343 - Epidemiologic Methods III
Credits: 4.0 [max 4.0]
Typically offered: Every Fall
Analysis/interpretation of data from various epidemiological study designs. SAS used to demonstrate epidemiological/statistical concepts in data analysis. prereq: [6342, 6451] with a grade of at least B- or instr consent
PUBH 6375 - Screening for Disease: a Double-Edged Sword?
Credits: 2.0 [max 2.0]
Typically offered: Every Fall
The earliest concept of screening for disease arose in the early 1900's with the advent of x-rays, which allowed, literally, for viewing lungs on a "screen". The rise of screening has also been attributed to public health approaches that were employed to "screen" out pollutants from water or to protect from vector-borne diseases. The earliest application of x-rays was to identify tuberculosis. Use of x-rays for tuberculosis led to realization that the technology allowed for the early diagnosis of latent tuberculosis, thereby offering the opportunity for treatment and control of its spread in the population. Another early application of screening was to determine the mental health suitability of army recruits in World War I. Since the World War II era, screening for disease has become a routine part of medical care. Thirty-six of the 55 U.S. Preventive Services Task Force evidence-based recommendations with an A or B grade are for screening in areas such as cancer, pregnancy, cardiovascular disease, mental health, and obesity, among others. Despite the U.S. Preventive Services Task Force imprimatur on screening recommendations, routine screening is complicated not only by conflicting evidence of its efficacy, leading to disagreement among professional medical societies, but also by increasing recognition of potential physical and psychological harms that may outweigh benefits. In addition, social, economic and political forces shape screening application and policy decisions, such as whether or not to provide insurance coverage for screening tests. For example, the 2009 U.S. Preventive Task Force recommendations to change the age at which to begin and frequency of mammography for breast cancer led to a public outcry. Advocacy groups and professional medical societies opposed to the changes lobbied Congress to keep the old recommendations. They claimed the revised recommendations would result in unnecessary deaths. However, it should be noted that reducing mammography frequency and narrowing the age range for women to be screened would also likely reduce reimbursement for clinical screening services. The aim of this course, then, is to provide a comprehensive overview of screening methods and evaluation, and to examine the efficacy, benefits versus harms, population uptake, screening promotion, and controversies surrounding specific screening tests for various health conditions. These include, but are not limited to, cancer, cardiovascular disease, infectious disease, mental health and newborn metabolic and genetic defects. Such controversies can range from overdiagnosis and unnecessary treatment, informed decision-making, screening policies, and ethical issues. The course is designed to appeal to students in Public Health, Nursing, Pharmacy, Medicine, genetic counseling and public policy.
PUBH 6381 - Genetics in Public Health in the Age of Precision Medicine
Credits: 2.0 [max 2.0]
Typically offered: Every Fall
Mechanisms of molecular genetics. Issues related to medical/public health genetics, including basis of human diversity, Human Genome Project, novel genetic mechanisms underlying diseases, ethical/legal issues. prereq: Grad student or professional school student or instr consent
PUBH 6383 - Vaccines
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Vaccines are one of the most successful public health interventions ever developed. Yet, fundamental misconceptions about how and why vaccines work and about the scientific evidence about their efficacy and safety limit the ability of public health professionals to prevent and control the spread of vaccine-preventable diseases. Vaccinology is the branch of infectious disease epidemiology that addresses these issues, building upon core concepts in epidemiologic methods and study designs to understand both the individual- and population-level impact of vaccines. In this graduate level course, students will focus on critical concepts and methods in epidemiology, infectious diseases, vaccinology, and public health needed to: 1) Understand the principles of infectious disease transmission dynamics that determine how and why vaccines reduce the burden of disease 2) Utilize epidemiologic methods and study designs to assess both individual and population-level vaccine efficacy/effectiveness 3) Develop and implement strategies to address the challenges of achieving and maintaining high vaccine coverage in diverse communities across the US and globally. More than 25 human diseases can be prevented by vaccination and dozens of novel and next-generation vaccines are currently under development. From ongoing efforts to eradicate polio worldwide to measles outbreaks in the US where the disease had once been eliminated to the development of fast-tracked Ebola vaccines during the West African outbreak, vaccines have taken center stage in the field of infectious diseases over the past several decades because of the incredible impact vaccines have had on saving lives, preventing disease, and preserving health. However, despite the success of vaccination programs against many serious diseases, challenges to designing, delivering, and maintaining trust in vaccines persist. Globally, vaccine-preventable diseases (pneumonia and diarrheal diseases including rotavirus) remain top causes of death in children under 5 years old. Yet vaccine access continues to be a challenge. The field of vaccinology allows us to examine, from an epidemiologic methods perspective, how and why vaccines protect individuals and populations and how and why we face challenges to achieving and maintaining high vaccine uptake among at-risk populations worldwide. In doing so, we gain the knowledge needed to develop strategies that can successfully protect all individuals from vaccine-preventable diseases. From the perspective of researchers, public health practitioners, and medical professionals, we will learn about numerous study designs to assess vaccine efficacy, effectiveness, and safety, and we will learn to apply communication skills critical to translating epidemiologic evidence about vaccines to the public. Specifically, we will draw upon the primary literature to understand concepts in infectious disease transmission dynamics, herd immunity, maternal immunity, and waning/boosting of immune responses. These concepts will set the foundation for understanding how and why vaccines protect both individuals and populations and how individuals interact with populations in complex ways. Throughout this course, we will apply principles of epidemiology and epi methods to understand how vaccines have successfully reduced the burden of disease in many different settings across the globe and to examine how the challenges of vaccine hesitancy, vaccine refusal, and lack of access threaten the advances that have been made in reducing the burden of infectious diseases. Students from many different disciplines who are interested in understanding why vaccines have been regarded as one of the greatest public health achievements of all time will gain a clear understanding of the essential role that they play in preventing disease and maintaining health populations.
PUBH 6385 - Epidemiology and Control of Infectious Diseases
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Principles and/ methods. Strategies for disease control and prevention, including immunization. Relevance of modes of transmission of specific agents for disease spread and prevention. Public health consequences of infectious diseases at local, national, and international levels.
PUBH 6386 - Cardiovascular Disease Epidemiology and Prevention
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Well-established risk factors for cardiovascular disease (CVD), prevention of CVD, and national recommendations for treatment/prevention. Emerging risk factors, current controversies in CVD. prereq: [PubH 6320 OR 6341 AND 6450] OR [equivalent] OR [permission of instructor]
PUBH 6387 - Cancer Epidemiology
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Epidemiologic aspects of cancer. Theories of carcinogenesis, patterns of incidence and mortality, site-specific risk factors. Issues of cancer control and prevention.
PUBH 6389 - Nutritional Epidemiology
Credits: 2.0 [max 2.0]
Typically offered: Fall Even Year
Nutrition/disease relationships through application of epidemiologic methods. Characterization of various exposures to food/nutrient intakes, biological basis for nutrition/disease relationships. Studies of specific chronic diseases and nutritional intake. Design/interpretation of studies using nutritional measures. prereq: [[6320 or 6330 or 6341], [Epidemiology MPH or Public Health Nutrition MPH or Epidemiology PhD student]] or instr consent
PUBH 6420 - Introduction to SAS Programming
Credits: 1.0 [max 1.0]
Typically offered: Periodic Fall & Summer
Use of SAS for analysis of biomedical data. Data manipulation/description. Basic statistical analyses (t-tests, chi-square, simple regression).
PUBH 6717 - Decision Analysis for Health Care
Credits: 2.0 [max 2.0]
Typically offered: Every Fall
Introduction to methods/range of applications of decision analysis and cost-effectiveness analysis in health care technology assessment, medical decision making, and health resource allocation.
PUBH 6803 - Conducting a Systematic Literature Review
Credits: 3.0 [max 3.0]
Grading Basis: OPT No Aud
Typically offered: Every Spring
Developing skills built on evidence-based practice. Draws on staff of Minnesota Evidence-based Practice Center. prereq: Basic knowledge of epidemiology
PUBH 6863 - Understanding Health Care Quality
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Fall
Introduction to assessing/assuring quality of care. Emphasizes both process and outcomes approaches, paralleling interest in appropriateness/effectiveness of care. Issues around creating needed behavioral changes.
PUBH 6864 - Conducting Health Outcomes Research
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Major concepts/principles in conducting health outcomes research that evaluates medical care. Developing study designs matched to research questions. Frequently used study designs. Evaluating health outcomes. Analytical approaches. prereq: Introductory course in epidemiology or health services research methods or instr consent
PUBH 7430 - Statistical Methods for Correlated Data
Credits: 3.0 [max 3.0]
Typically offered: Every Fall
Correlated data arise in many situations, particularly when observations are made over time and space or on individuals who share certain underlying characteristics. This course covers techniques for exploring and describing correlated data, along with statistical methods for estimating population parameters (mostly means) from these data. The focus will be primarily on generalized linear models (both with and without random effects) for normally and non-normally distributed data. Wherever possible, techniques will be illustrated using real-world examples. Computing will be done using R and SAS.
PUBH 7440 - Introduction to Bayesian Analysis
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Introduction to Bayesian methods. Comparison with traditional frequentist methods. Emphasizes data analysis via modern computing methods: Gibbs sampler, WinBUGS software package. prereq: [[7401 or STAT 5101 or equiv], [public health MPH or biostatistics or statistics] grad student] or instr consent
PUBH 7445 - Statistics for Human Genetics and Molecular Biology
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Introduction to statistical problems arising in molecular biology. Problems in physical mapping (radiation hybrid mapping, DDP), genetic mapping (pedigree analysis, lod scores, TDT), biopolymer sequence analysis (alignment, motif recognition), and micro array analysis. prereq: [6450, [6451 or equiv]] or instr consent; background in molecular biology recommended
PUBH 7450 - Survival Analysis
Credits: 3.0 [max 3.0]
Prerequisites: 7406, [STAT 5102 or STAT 8102]
Typically offered: Every Fall
Statistical methodologies in analysis of survival data. Kaplan-Meier estimator, Cox's proportional hazards multiple regression model, time-dependent covariates, analysis of residuals, multiple failure outcomes. Typical biomedical applications, including clinical trials and person-years data. prereq: 7406, [STAT 5102 or STAT 8102]
PUBH 7470 - Study Designs in Biomedical Research
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Diagnostic medicine, including methods for ROC curve. Bioassays. Early-phase clinical trials, methods including dose escalation, toxicity, and monitoring. Quality of life. prereq: [[6450, 6451] or equiv], [grad student in biostatistics or statistics or clinical research], familiarity with SAS
TMDP 8441 - Seminar in Temporomandibular Disorders & Orofacial Pain
Credits: 1.0 [max 1.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall, Spring & Summer
Advanced topics on theories and application of recently developed techniques of data collection, diagnostic strategies, and management.
VMED 5080 - Problems in Veterinary Epidemiology and Public Health
Credits: 1.0 -3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall & Spring
Individual study on problem of interest to epidemiology or public health student.
VMED 5165 - Surveillance of Foodborne Diseases and Food Safety Hazards
Credits: 2.0 [max 2.0]
Course Equivalencies: PubH 5181/VMed 5165
Typically offered: Every Spring
Principles/methods for surveillance of foodborne diseases. Investigation of outbreaks. Assessment of food safety hazards. Focuses on integration of epidemiologic/lab methods. prereq: [PUBH 5330, [professional school or grad student]] or instr consent
VMED 8090 - Epidemiology of Zoonoses and Diseases Common to Animals and Humans
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall & Spring
Major human zoonotic diseases, methods of transmission, diagnosis, control, and prevention. prereq: Epidemiology and infectious disease course or instr consent
PUBH 8777 - Thesis Credits: Master's
Credits: 1.0 -18.0 [max 50.0]
Grading Basis: No Grade
Typically offered: Every Fall, Spring & Summer
(No description) prereq: Max 18 cr per semester or summer; 10 cr total required [Plan A only]
DENT 8100 - Topics in Advanced Periodontology: Literature Review
Credits: 2.0 [max 2.0]
Typically offered: Every Fall, Spring & Summer
State-of-the-art information on a variety of topics concerning risk factors and therapeutic modalities for periodontal disease.
DENT 8120 - Advanced Principles and Techniques of Orofacial Pain Disorders
Credits: 2.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Interdisciplinary study of theory, principles, epidemiology, mechanisms associated with TMJ/craniofacial pain disorders. Basis for scientific understanding of diagnostic/management strategies. prereq: Participation in TMJ, orofacial pain advanced education program
DENT 8121 - Current Literature in TMD and Orofacial Pain
Credits: 1.0 [max 1.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall, Spring & Summer
Review of current literature/how it relates to past literature. Theories on pain, philosophies of management.
ECP 5220 - Regulatory Issues in Drug Research
Credits: 2.0 [max 2.0]
Typically offered: Every Fall
Regulatory issues encountered in conducting drug research trials. Performing different aspects of clinical trials. Lectures, readings, small group discussions, homework assignments. prereq: ECP grad student or Pharm.D. professional student or instr consent
ECP 5620 - Drug Metabolism and Disposition
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Spring Odd Year
Oxidatative/conjugative enzymes systems involved in human drug metabolism/disposition. Various in vitro models used to evaluate drug metabolism or chemical entity, pros/cons of each. Factors involved in conducting in vivo studies. Components used to predict in vivo drug disposition from in vivo studies. prereq: Grad student or instr consent
ECP 8100 - Seminar
Credits: 1.0 [max 8.0]
Typically offered: Every Fall & Spring
Selected topics in experimental/clinical pharmacology. prereq: ECP grad student or instr consent
MICA 8013 - Translational Cancer Research
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Clinical issues in cancer research. Discuss translational research projects as they pertain to a variety of cancers. prereq: 8004 or instr consent
NURS 5925 - Grant Writing and Critique
Credits: 1.0 [max 1.0]
Typically offered: Every Spring
Self-paced course. Online modular format. How to write/critique grants. Students select a research or program grant to critique, applying knowledge obtained through learning modules. prereq: Grad student or instr consent
NURS 6102 - Family Health Theory
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Fall
Emerging theory in family nursing science, related theories. Research on family systems for structuring systemic framework to examine clinical problems related to family health care. Applies family health theories to selected phenomena of interest to health care. prereq: 6200 or instr consent
NURS 7202 - Moral and Ethical Positions and Actions in Nursing
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall & Spring
Normative ethics and theoretical underpinnings for positions taken. Implications for subsequent action. Morally defensible positions on health-related issues, corresponding actions from perspective of nursing.
NURS 8152 - Scholarship in Health Care Ethics
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Fall
Analyze the underlying values in the concepts and discourses of health/disease. Evaluate ethical frameworks regarding their capability to address issues in health care. Analyze/discuss issues related to the responsible and ethical conduct of research. prereq: Doctoral student or instr consent
NURS 8172 - Theory and Theory Development for Research
Credits: 3.0 [max 3.0]
Typically offered: Periodic Fall & Spring
Paradigms in nursing/health, associated methods of scientific/scholarly inquiry. Inductive/deductive techniques for theory development Theory-testing using data obtained under controlled conditions. prereq: Doctoral student
NURS 8173 - Principles and Methods of Implementing Research
Credits: 3.0 [max 3.0]
Course Equivalencies: 01044 - Nurs 8173/SAPh 8173
Typically offered: Every Spring
Integrates scientific, statistical, and practical aspects of research. Inter-relationships among design, sample selections, subject access, human subjects requirements, instrument selection and evaluation, data management, analyses plans, grant writing, and research career issues. Field experiences required. prereq: 8114 or other 8xxx grad research methods course, 2 grad stat courses;
NURS 8175 - Quantitative Research Design and Methods
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
Designs for quantitative description and quasi-experimental/experimental evaluation of scientific problems across domain of nursing. Evaluation of logic of design/attribution of causality from health and social science perspectives. prereq: [PhD student in nursing, advanced applied statistics] or instr consent
PHAR 6224 - Pharmacogenomics: Genetic Basis for Variability in Drug Response
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Spring
Theory/practice of pharmacogenomics. Principles of human genetics/genomics. Applications to scientific education, problems in drug therapy optimization, patient care. prereq: At least 3rd year or later in healthcare or related program or equivalent experience or instr consent
PHCL 5111 - Pharmacogenomics
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Human genetic variation, its implications. Functional genomics, pharmacogenomics, toxicogenomics, proteomics. Interactive, discussion-based course. prereq: Grad student or instr consent Keywords: Pharmacology, Pharmacogenomics, Toxicogenomics, Proteomics, Genetics, Drug
PUBH 6181 - Surveillance of Foodborne Diseases and Food Safety Hazards
Credits: 2.0 [max 2.0]
Course Equivalencies: PubH 5181/VMed 5165
Typically offered: Every Fall
Principles/methods for surveillance of foodborne diseases. Investigation of outbreaks, assessment of food safety hazards. Focuses on integration of epidemiologic/lab methods.
PUBH 6303 - Clinical Research Project Seminar
Credits: 2.0 [max 2.0]
Grading Basis: S-N only
Typically offered: Every Spring
Students will present their thesis and give and receive feedback. Students must have their project underway.
PUBH 6325 - Data Processing with PC-SAS
Credits: 1.0 [max 1.0]
Typically offered: Every Spring
Introduction to methods for transferring/processing existing data sources. Emphasizes hands-on approach to pre-statistical data processing and analysis with PC-SAS statistical software with a Microsoft Windows operating system.
PUBH 6343 - Epidemiologic Methods III
Credits: 4.0 [max 4.0]
Typically offered: Every Fall
Analysis/interpretation of data from various epidemiological study designs. SAS used to demonstrate epidemiological/statistical concepts in data analysis. prereq: [6342, 6451] with a grade of at least B- or instr consent
PUBH 6348 - Writing Research Grants
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
Focuses on NIH research grants. Mechanisms of grant writing: specific aims, hypotheses, innovation, background, approaches, evaluation analyses, principles of informed consent, budget development, and grant-review process.
PUBH 6375 - Screening for Disease: a Double-Edged Sword?
Credits: 2.0 [max 2.0]
Typically offered: Every Fall
The earliest concept of screening for disease arose in the early 1900's with the advent of x-rays, which allowed, literally, for viewing lungs on a "screen". The rise of screening has also been attributed to public health approaches that were employed to "screen" out pollutants from water or to protect from vector-borne diseases. The earliest application of x-rays was to identify tuberculosis. Use of x-rays for tuberculosis led to realization that the technology allowed for the early diagnosis of latent tuberculosis, thereby offering the opportunity for treatment and control of its spread in the population. Another early application of screening was to determine the mental health suitability of army recruits in World War I. Since the World War II era, screening for disease has become a routine part of medical care. Thirty-six of the 55 U.S. Preventive Services Task Force evidence-based recommendations with an A or B grade are for screening in areas such as cancer, pregnancy, cardiovascular disease, mental health, and obesity, among others. Despite the U.S. Preventive Services Task Force imprimatur on screening recommendations, routine screening is complicated not only by conflicting evidence of its efficacy, leading to disagreement among professional medical societies, but also by increasing recognition of potential physical and psychological harms that may outweigh benefits. In addition, social, economic and political forces shape screening application and policy decisions, such as whether or not to provide insurance coverage for screening tests. For example, the 2009 U.S. Preventive Task Force recommendations to change the age at which to begin and frequency of mammography for breast cancer led to a public outcry. Advocacy groups and professional medical societies opposed to the changes lobbied Congress to keep the old recommendations. They claimed the revised recommendations would result in unnecessary deaths. However, it should be noted that reducing mammography frequency and narrowing the age range for women to be screened would also likely reduce reimbursement for clinical screening services. The aim of this course, then, is to provide a comprehensive overview of screening methods and evaluation, and to examine the efficacy, benefits versus harms, population uptake, screening promotion, and controversies surrounding specific screening tests for various health conditions. These include, but are not limited to, cancer, cardiovascular disease, infectious disease, mental health and newborn metabolic and genetic defects. Such controversies can range from overdiagnosis and unnecessary treatment, informed decision-making, screening policies, and ethical issues. The course is designed to appeal to students in Public Health, Nursing, Pharmacy, Medicine, genetic counseling and public policy.
PUBH 6381 - Genetics in Public Health in the Age of Precision Medicine
Credits: 2.0 [max 2.0]
Typically offered: Every Fall
Mechanisms of molecular genetics. Issues related to medical/public health genetics, including basis of human diversity, Human Genome Project, novel genetic mechanisms underlying diseases, ethical/legal issues. prereq: Grad student or professional school student or instr consent
PUBH 6383 - Vaccines
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Vaccines are one of the most successful public health interventions ever developed. Yet, fundamental misconceptions about how and why vaccines work and about the scientific evidence about their efficacy and safety limit the ability of public health professionals to prevent and control the spread of vaccine-preventable diseases. Vaccinology is the branch of infectious disease epidemiology that addresses these issues, building upon core concepts in epidemiologic methods and study designs to understand both the individual- and population-level impact of vaccines. In this graduate level course, students will focus on critical concepts and methods in epidemiology, infectious diseases, vaccinology, and public health needed to: 1) Understand the principles of infectious disease transmission dynamics that determine how and why vaccines reduce the burden of disease 2) Utilize epidemiologic methods and study designs to assess both individual and population-level vaccine efficacy/effectiveness 3) Develop and implement strategies to address the challenges of achieving and maintaining high vaccine coverage in diverse communities across the US and globally. More than 25 human diseases can be prevented by vaccination and dozens of novel and next-generation vaccines are currently under development. From ongoing efforts to eradicate polio worldwide to measles outbreaks in the US where the disease had once been eliminated to the development of fast-tracked Ebola vaccines during the West African outbreak, vaccines have taken center stage in the field of infectious diseases over the past several decades because of the incredible impact vaccines have had on saving lives, preventing disease, and preserving health. However, despite the success of vaccination programs against many serious diseases, challenges to designing, delivering, and maintaining trust in vaccines persist. Globally, vaccine-preventable diseases (pneumonia and diarrheal diseases including rotavirus) remain top causes of death in children under 5 years old. Yet vaccine access continues to be a challenge. The field of vaccinology allows us to examine, from an epidemiologic methods perspective, how and why vaccines protect individuals and populations and how and why we face challenges to achieving and maintaining high vaccine uptake among at-risk populations worldwide. In doing so, we gain the knowledge needed to develop strategies that can successfully protect all individuals from vaccine-preventable diseases. From the perspective of researchers, public health practitioners, and medical professionals, we will learn about numerous study designs to assess vaccine efficacy, effectiveness, and safety, and we will learn to apply communication skills critical to translating epidemiologic evidence about vaccines to the public. Specifically, we will draw upon the primary literature to understand concepts in infectious disease transmission dynamics, herd immunity, maternal immunity, and waning/boosting of immune responses. These concepts will set the foundation for understanding how and why vaccines protect both individuals and populations and how individuals interact with populations in complex ways. Throughout this course, we will apply principles of epidemiology and epi methods to understand how vaccines have successfully reduced the burden of disease in many different settings across the globe and to examine how the challenges of vaccine hesitancy, vaccine refusal, and lack of access threaten the advances that have been made in reducing the burden of infectious diseases. Students from many different disciplines who are interested in understanding why vaccines have been regarded as one of the greatest public health achievements of all time will gain a clear understanding of the essential role that they play in preventing disease and maintaining health populations.
PUBH 6385 - Epidemiology and Control of Infectious Diseases
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Principles and/ methods. Strategies for disease control and prevention, including immunization. Relevance of modes of transmission of specific agents for disease spread and prevention. Public health consequences of infectious diseases at local, national, and international levels.
PUBH 6386 - Cardiovascular Disease Epidemiology and Prevention
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Well-established risk factors for cardiovascular disease (CVD), prevention of CVD, and national recommendations for treatment/prevention. Emerging risk factors, current controversies in CVD. prereq: [PubH 6320 OR 6341 AND 6450] OR [equivalent] OR [permission of instructor]
PUBH 6387 - Cancer Epidemiology
Credits: 2.0 [max 2.0]
Typically offered: Every Spring
Epidemiologic aspects of cancer. Theories of carcinogenesis, patterns of incidence and mortality, site-specific risk factors. Issues of cancer control and prevention.
PUBH 6389 - Nutritional Epidemiology
Credits: 2.0 [max 2.0]
Typically offered: Fall Even Year
Nutrition/disease relationships through application of epidemiologic methods. Characterization of various exposures to food/nutrient intakes, biological basis for nutrition/disease relationships. Studies of specific chronic diseases and nutritional intake. Design/interpretation of studies using nutritional measures. prereq: [[6320 or 6330 or 6341], [Epidemiology MPH or Public Health Nutrition MPH or Epidemiology PhD student]] or instr consent
PUBH 6420 - Introduction to SAS Programming
Credits: 1.0 [max 1.0]
Typically offered: Periodic Fall & Summer
Use of SAS for analysis of biomedical data. Data manipulation/description. Basic statistical analyses (t-tests, chi-square, simple regression).
PUBH 6717 - Decision Analysis for Health Care
Credits: 2.0 [max 2.0]
Typically offered: Every Fall
Introduction to methods/range of applications of decision analysis and cost-effectiveness analysis in health care technology assessment, medical decision making, and health resource allocation.
PUBH 6803 - Conducting a Systematic Literature Review
Credits: 3.0 [max 3.0]
Grading Basis: OPT No Aud
Typically offered: Every Spring
Developing skills built on evidence-based practice. Draws on staff of Minnesota Evidence-based Practice Center. prereq: Basic knowledge of epidemiology
PUBH 6863 - Understanding Health Care Quality
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Fall
Introduction to assessing/assuring quality of care. Emphasizes both process and outcomes approaches, paralleling interest in appropriateness/effectiveness of care. Issues around creating needed behavioral changes.
PUBH 6864 - Conducting Health Outcomes Research
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Major concepts/principles in conducting health outcomes research that evaluates medical care. Developing study designs matched to research questions. Frequently used study designs. Evaluating health outcomes. Analytical approaches. prereq: Introductory course in epidemiology or health services research methods or instr consent
PUBH 7430 - Statistical Methods for Correlated Data
Credits: 3.0 [max 3.0]
Typically offered: Every Fall
Correlated data arise in many situations, particularly when observations are made over time and space or on individuals who share certain underlying characteristics. This course covers techniques for exploring and describing correlated data, along with statistical methods for estimating population parameters (mostly means) from these data. The focus will be primarily on generalized linear models (both with and without random effects) for normally and non-normally distributed data. Wherever possible, techniques will be illustrated using real-world examples. Computing will be done using R and SAS.
PUBH 7440 - Introduction to Bayesian Analysis
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Introduction to Bayesian methods. Comparison with traditional frequentist methods. Emphasizes data analysis via modern computing methods: Gibbs sampler, WinBUGS software package. prereq: [[7401 or STAT 5101 or equiv], [public health MPH or biostatistics or statistics] grad student] or instr consent
PUBH 7445 - Statistics for Human Genetics and Molecular Biology
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Introduction to statistical problems arising in molecular biology. Problems in physical mapping (radiation hybrid mapping, DDP), genetic mapping (pedigree analysis, lod scores, TDT), biopolymer sequence analysis (alignment, motif recognition), and micro array analysis. prereq: [6450, [6451 or equiv]] or instr consent; background in molecular biology recommended
PUBH 7450 - Survival Analysis
Credits: 3.0 [max 3.0]
Prerequisites: 7406, [STAT 5102 or STAT 8102]
Typically offered: Every Fall
Statistical methodologies in analysis of survival data. Kaplan-Meier estimator, Cox's proportional hazards multiple regression model, time-dependent covariates, analysis of residuals, multiple failure outcomes. Typical biomedical applications, including clinical trials and person-years data. prereq: 7406, [STAT 5102 or STAT 8102]
PUBH 7470 - Study Designs in Biomedical Research
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Diagnostic medicine, including methods for ROC curve. Bioassays. Early-phase clinical trials, methods including dose escalation, toxicity, and monitoring. Quality of life. prereq: [[6450, 6451] or equiv], [grad student in biostatistics or statistics or clinical research], familiarity with SAS
TMDP 8441 - Seminar in Temporomandibular Disorders & Orofacial Pain
Credits: 1.0 [max 1.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall, Spring & Summer
Advanced topics on theories and application of recently developed techniques of data collection, diagnostic strategies, and management.
VMED 5080 - Problems in Veterinary Epidemiology and Public Health
Credits: 1.0 -3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall & Spring
Individual study on problem of interest to epidemiology or public health student.
VMED 5165 - Surveillance of Foodborne Diseases and Food Safety Hazards
Credits: 2.0 [max 2.0]
Course Equivalencies: PubH 5181/VMed 5165
Typically offered: Every Spring
Principles/methods for surveillance of foodborne diseases. Investigation of outbreaks. Assessment of food safety hazards. Focuses on integration of epidemiologic/lab methods. prereq: [PUBH 5330, [professional school or grad student]] or instr consent
VMED 8090 - Epidemiology of Zoonoses and Diseases Common to Animals and Humans
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall & Spring
Major human zoonotic diseases, methods of transmission, diagnosis, control, and prevention. prereq: Epidemiology and infectious disease course or instr consent
PUBH 8394 - Plan B Project: Clinical Research
Credits: 1.0 -10.0 [max 10.0]
Grading Basis: S-N only
Typically offered: Every Fall, Spring & Summer
Directed research toward completion of culminating experience project in clinical research.