Twin Cities campus

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Twin Cities Campus

Stem Cell Biology Minor

Stem Cell Institute
Medical School
Link to a list of faculty for this program.
Contact Information
Stem Cell Institute, 2001 6th Street SE, Mail Code 2873, Minneapolis, MN 55455-3007 (612-625-0602; fax: 612-624-2436)
Email: scbgrad@umn.edu
  • Program Type: Graduate minor related to major
  • Requirements for this program are current for Fall 2022
  • Length of program in credits (doctoral): 12
  • This program does not require summer semesters for timely completion.
The stem cell biology minor is available to PhD students in relevant programs such as MCDB&G, MiCaB, pharmacology, microbiology, bio-engineering, or a medical or veterinary medicine school program, and who have an interest in stem cell biology. It offers training in stem cell biology, which is a rapidly growing interdisciplinary field that rests on foundations provided by molecular, cellular, and developmental biology. Students will take lecture and seminar courses, interact with members of the Stem Cell Institute through participation in research seminar and journal clubs, and conduct stem cell research in the laboratory of a stem cell biology graduate program faculty member.
Program Delivery
  • via classroom (the majority of instruction is face-to-face)
Prerequisites for Admission
Special Application Requirements:
Applicants must be admitted to a Ph.D. program and obtain approval from the Stem Cell Biology director of graduate studies.
For an online application or for more information about graduate education admissions, see the General Information section of this website.
Program Requirements
Use of 4xxx courses toward program requirements is permitted under certain conditions with adviser approval.
In addition to course requirements, the student's research project must be done in the lab of a Stem Cell Biology faculty member; therefore, students must obtain approval from the Stem Cell Biology director of graduate studies prior to declaring the minor. The minimum GPA for minor field coursework is 3.00.
Program Sub-plans
Students are required to complete one of the following sub-plans.
Students may not complete the program with more than one sub-plan.
Doctoral
Required Courses (5 credits)
Take the following required courses on the A-F grade basis.
SCB 5054 - Stem Cell Institute Research Seminar and Journal Club (2.0 cr)
SCB 8181 - Stem Cell Biology (3.0 cr)
Electives (7 credits)
Select at least seven elective credits in consultation with the Stem Cell Biology director of graduate studies to complete the 12-credit minimum. Elective courses should be taken on the A-F grade basis. Courses required to meet the student's major field requirement cannot be applied to the minor.
Take 7 or more credit(s) from the following:
· BIOC 8007 - Molecular Biology of the Genome (2.0 cr)
· BIOC 8008 - Molecular Biology of the Transcriptome (2.0 cr)
· BIOC 8401 - Ethics, Public Policy, and Careers in Molecular and Cellular Biology (1.0 cr)
· BMEN 5041 - Tissue Engineering (3.0 cr)
· BMEN 5351 - Cell Engineering (3.0 cr)
· BMEN 5701 - Cancer Bioengineering (3.0 cr)
· BTHX 5000 - Topics in Bioethics (1.0-4.0 cr)
· BTHX 5100 - Introduction to Clinical Ethics (3.0 cr)
· BTHX 5110 - Ethical Issues in Pediatrics (2.0 cr)
· BTHX 5210 - Ethics of Human Subjects Research (3.0 cr)
· BTHX 5325 - Biomedical Ethics (3.0 cr)
· BTHX 5400 - Intro Ethics in Hlth Policy (3.0 cr)
· BTHX 8000 - Advanced Topics in Bioethics (1.0-4.0 cr)
· CMB 5910 - Grantwriting: What Makes a Winning Proposal? (2.0 cr)
· CSCI 5461 - Functional Genomics, Systems Biology, and Bioinformatics (3.0 cr)
· CSCI 5465 - Introduction to Computing for Biologists (3.0 cr)
· GCD 5005 - Computer Programming for Biology (3.0 cr)
· GCD 5036 - Molecular Cell Biology (3.0 cr)
· GCD 8008 - Mammalian Gene Transfer and Genome Engineering (2.0 cr)
· GCD 8131 - Advanced Molecular Genetics and Genomics (3.0 cr)
· GCD 8141 - Computational Genomics (3.0 cr)
· GCD 8151 - Cellular Biochemistry and Cell Biology (2.0-4.0 cr)
· GCD 8161 - Advanced Cell Biology and Development (2.0 cr)
· MICA 8003 - Immunity and Immunopathology (4.0 cr)
· MICA 8004 - Cellular and Cancer Biology (4.0 cr)
· MICA 8014 - Small RNA Biology (2.0 cr)
· MILI 6235 - Pharmaceutical Industry: Business and Policy (2.0 cr)
· MILI 6726 - Medical Device Industry: Business and Public Policy (2.0 cr)
· MILI 6985 - The Health Care Marketplace (2.0 cr)
· MILI 6995 - Medical Industry Valuation Laboratory (2.0 cr)
· NSC 5461 - Cellular and Molecular Neuroscience (3.0 cr)
· NSC 8026 - Neuro-Immune Interactions (3.0 cr)
· NSC 8211 - Developmental Neurobiology (2.0-4.0 cr)
· NSCI 5101 - Neurobiology I: Molecules, Cells, and Systems (3.0 cr)
· NSCI 5501 - Neurodegenerative Diseases, Mechanisms to Therapies (3.0 cr)
· PHCL 5110 - Introduction to Pharmacology (3.0 cr)
· PHCL 5112 - Foundations of Biomedical Research (1.0-2.0 cr)
· PHSL 5061 - Principles of Physiology for Biomedical Engineering (4.0 cr)
· PHSL 5197 - Stress Physiology (1.0-3.0 cr)
· PHSL 5211 - Physiology of Inflammation in Disease (3.0 cr)
· PHSL 5221 - Systems and Computational Physiology (3.0 cr)
· PHSL 5510 - Advanced Cardiac Physiology and Anatomy (2.0-3.0 cr)
· PHSL 8242 - Professional Skills Development for Biomedical Scientists (2.0 cr)
· PSY 5063 - Introduction to Functional MRI (3.0 cr)
· PUBH 6450 - Biostatistics I (4.0 cr)
· PUBH 6451 - Biostatistics II (4.0 cr)
 
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SCB 5054 - Stem Cell Institute Research Seminar and Journal Club
Credits: 2.0 [max 6.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall & Spring
Students attend weekly Stem Cell Institute research seminars and journal clubs, write brief summaries, participate in journal club, and present original research paper. prereq: Acceptance into stem cell biology [master's prog or PhD minor prog] or instr consent
SCB 8181 - Stem Cell Biology
Credits: 3.0 [max 3.0]
Course Equivalencies: GCD 8181/SCB 8181
Typically offered: Every Fall
Stem cell research and its applications. Critical analysis, written summaries/critiques, oral presentations. prereq: [[GCD 4034], [GCD 4161]] or equiv or instr consent
BIOC 8007 - Molecular Biology of the Genome
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
This course explores the molecular biology of the eukaryotic genome and transcriptome, focusing on fundamental genetic processes, molecular mechanisms, and their relationships to biology and disease. Students gain a firm understanding of the key concepts and techniques through lectures, reading, and discussions. Students learn to critically analyze scientific papers through student-led presentations and discussions. They gain experience in articulating scientific questions, formulating testable hypotheses, and designing experiments. This course promotes development of science writing skills.
BIOC 8008 - Molecular Biology of the Transcriptome
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
This course explores the molecular biology of the eukaryotic genome and transcriptome, focusing on fundamental genetic processes, molecular mechanisms, and their relationships to biology and disease. Students gain a firm understanding of the key concepts and techniques through lectures, reading, and discussions. Students learn to critically analyze scientific papers through student-led presentations and discussions. They gain experience in articulating scientific questions, formulating testable hypotheses, and designing experiments. This course promotes development of science writing skills.
BIOC 8401 - Ethics, Public Policy, and Careers in Molecular and Cellular Biology
Credits: 1.0 [max 2.0]
Course Equivalencies: Bioc 8401/GCD 8401
Grading Basis: S-N or Aud
Typically offered: Every Spring
Ethics of scientific investigation from viewpoint of western scientific enterprise. Relationship between science, culture, and public policies. Careers in molecular/cellular biology. Nontraditional career tracks. Invited speakers, case studies, small-group discussions, lectures. prereq: Grad student in [BMBB or MCDBconcurrent registration is required (or allowed) in G]
BMEN 5041 - Tissue Engineering
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Fundamentals of wound healing and tissue repair; characterization of cell-matrix interactions; case study of engineered tissues, including skin, bone marrow, liver, vessel, and cartilage; regulation of biomaterials and engineered tissues. prereq: CSE upper div or grad student or med student or instr consent
BMEN 5351 - Cell Engineering
Credits: 3.0 [max 3.0]
Typically offered: Periodic Fall & Spring
Engineering approaches to cell-related phenomena important to cell/tissue engineering. Receptor/ligand binding. Trafficking/signaling processes. Applications to cell proliferation, adhesion, and motility. Cell-matrix interactions. prereq: [2401, [2501 or concurrent registration is required (or allowed) in 5501], [MATH 2243 or MATH 2373]] or CSE upper div or grad student or instr consent
BMEN 5701 - Cancer Bioengineering
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
Cancer-specific cell, molecular/genetics events. Quantitative applications of bioinformatics/systems biology, optical imaging, cell/matrix mechanics. Drug transport (with some examination of design of novel therapeutics). prereq: [Upper division CSE undergraduate, CSE graduate student] or instr consent
BTHX 5000 - Topics in Bioethics
Credits: 1.0 -4.0 [max 8.0]
Typically offered: Periodic Fall & Spring
Bioethics topics of contemporary interest. Topics specified in Class Schedule.
BTHX 5100 - Introduction to Clinical Ethics
Credits: 3.0 [max 3.0]
Typically offered: Every Fall & Spring
Healthcare is full of gray areas, high stakes situations, and tensions between personal and professional values. This course explores the moral nature of the healthcare professions and common values-based conflicts in clinical practice. By examining everyday cases, exploring current issues in healthcare, and developing habits of reflective practice, learners will have the opportunity to recognize and respond to moral uncertainties that arise in the interprofessional clinical environment. The course presents practical knowledge and skills needed for ethics deliberation and decision making. This is a blended instruction course where students can expect a majority of sessions held in-person and occasional online sessions.
BTHX 5110 - Ethical Issues in Pediatrics
Credits: 2.0 [max 2.0]
Typically offered: Fall Odd Year
Using real pediatric cases, we will examine some of the most pressing ethical issues faced by clinical teams, patients and families, and ethics consultants. Topics include decision-making for children at the end-of-life, care of extremely premature infants, conceptions of disability, adolescents? independence from their guardians in decision-making and confidentiality protections, research conducted with children, Child Protective Services in the lives of children & families, and prioritizing children for scarce resources in public health emergencies. Through robust classroom discussions, we will consider these complex issues from a diversity of perspectives. This course is intended for professional and academic disciplines working with children such as medicine, nursing, psychology, social work, law, public health, and education, as well as child development, anthropology, and philosophy.
BTHX 5210 - Ethics of Human Subjects Research
Credits: 3.0 [max 3.0]
Typically offered: Fall Even Year
Issues in ethics of human subjects research. prereq: Grad student or instr consent
BTHX 5325 - Biomedical Ethics
Credits: 3.0 [max 3.0]
Course Equivalencies: Bthx 5325/Phil 5325
Typically offered: Every Fall
This online course examines contemporary issues in bioethics, focusing on practical issues that arise in clinical care, public health, and health policy settings. The course also introduces conceptual frameworks and methods to analyze these issues, though the emphasis will be on challenges faced by patients and their loved ones, health professionals, and policy makers, not on ethical theory. To fully understand and evaluate these complex issues, it is critical that we consider them from a diversity of perspectives. Hence, we will spend most of our time in class discussion, openly and respectfully listening to and engaging with each other in interdisciplinary/interprofessional conversation. Class meetings will be fully online via Zoom; no in-person meetings will be required. This course has been approved for Interprofessional Education (IPE) credit for health professions students. prereq: Jr or sr or grad student or instr consent.
BTHX 5400 - Intro Ethics in Hlth Policy
Credits: 3.0 [max 3.0]
Typically offered: Spring Even Year
Topics vary to reflect issues of current significance. Relates to law/politics as appropriate but focuses on moral analyses of policy issues. prereq: Grad student or professional student or instr consent
BTHX 8000 - Advanced Topics in Bioethics
Credits: 1.0 -4.0 [max 8.0]
Typically offered: Every Fall & Spring
Advanced study of bioethics topics of contemporary interest. prereq: Grad or professional student
CMB 5910 - Grantwriting: What Makes a Winning Proposal?
Credits: 2.0 [max 2.0]
Course Equivalencies: CMB 5910/VMed 5910
Typically offered: Every Spring
Components of a strong proposal. Grant submission process. What reviewers look for. How to locate grant announcements that match reserach interests.
CSCI 5461 - Functional Genomics, Systems Biology, and Bioinformatics
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Computational methods for analyzing, integrating, and deriving predictions from genomic/proteomic data. Analyzing gene expression, proteomic data, and protein-protein interaction networks. Protein/gene function prediction, Integrating diverse data, visualizing genomic datasets. prereq: 3003 or 4041 or instr consent
CSCI 5465 - Introduction to Computing for Biologists
Credits: 3.0 [max 3.0]
Course Equivalencies: CSci 3003/CSci 5465
Typically offered: Fall Odd Year
This course is designed for graduate students in biology or other related sciences that wish to learn fundamental computing skills that will enable them to develop their own computational approaches for meaningful interpretation of scientific data. Students will complete programming assignments in Python and R. No previous programming knowledge assumed. Prereq: Introductory biology course; non-CSE students only.
GCD 5005 - Computer Programming for Biology
Credits: 3.0 [max 3.0]
Typically offered: Every Fall
Computer programming skills with applications in biology. Design/build new computer programs for applications in cell/developmental biology, including modeling of biological processes, advanced data analysis, automated image analysis. prereq: BIOL 4003 or BIOL 4004 or GCD 3033 or CBS grad or BMBB or MCDB&G grad student, general statistics course
GCD 5036 - Molecular Cell Biology
Credits: 3.0 [max 3.0]
Typically offered: Every Fall
Analysis of dynamic cellular activities at the molecular level in cell biological fields that are experiencing new research advances not yet reflected in textbooks. Significant emphasis is placed on understanding the experimental basis of our current knowledge of cellular processes through analysis of scientific papers. Project and presentation-based assessments of learning outcomes. prereq: BIOL 4004 or GCD 4005W or grad
GCD 8008 - Mammalian Gene Transfer and Genome Engineering
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Current gene transfer and genome engineering technology. Applications of genetic modifications in animals, particularly transgenic animals and human gene therapy. prereq: instr consent
GCD 8131 - Advanced Molecular Genetics and Genomics
Credits: 3.0 [max 3.0]
Typically offered: Every Fall & Spring
Literature-based course in modern molecular genetic and genomic analysis. Students will gain a deep understanding of the fundamental molecular mechanisms controlling inheritance in biological systems. Students will gain a facility in thinking critically and creatively about how genes work at cellular, organismal, and transgenerational levels. Course instruction emphasizes active-learning approaches, student presentations, and group projects. prereq: [3022 or BIOL 4003], [BIOC 3021 or BIOC 4331] or instr consent
GCD 8141 - Computational Genomics
Credits: 3.0 [max 3.0]
Typically offered: Every Spring
Genomic data is increasingly prevalent in biology today, and the ability to analyze and interpret genomic data is an important skill for a career in biology. This class will provide you with an overview of the emerging genomics field by review and discussion of seminal papers, combined with hands-on analysis of genomics data. At the end of this course, you will gain a broad view of cutting edge research in the field of genomics, gain experience in analysis and interpretation of genomic data, and learn basic computer programming, data visualization, and bioinformatics skills using R and UNIX.
GCD 8151 - Cellular Biochemistry and Cell Biology
Credits: 2.0 -4.0 [max 4.0]
Grading Basis: A-F only
Typically offered: Every Fall
This course introduces graduate students to fundamental concepts of Biochemical Unity (Part 1) and Cell Theory (Part 2). For Part 1, we will discuss matter of life, equilibrium, entropy & law of mass action, two state systems, random walks & diffusion, rate equations of chemical reactions, and explore how they relate to regulation of biological networks (gene regulation and signal transduction). For Part 2 we will focus on properties of biological membranes, membrane trafficking, protein import & degradation, nuclear structures and their function, as well as molecular motors, cytoskeletal dynamics, and mitosis. The course assumes students have had previous undergraduate courses in cell biology, biochemistry and genetics. prereq: [[[4034 or 8121 or BioC 8002], Biol 4004] or BMBB or MCDBG grad student] or instr consent
GCD 8161 - Advanced Cell Biology and Development
Credits: 2.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
The advanced cell and developmental biology of embryos, taught through in-depth, comparative analysis of historical and current primary research articles that illustrate developmental mechanisms and experimental approaches in key invertebrate and vertebrate model organisms. prereq:[BMBB or MCDBG grad student] or [GCD 4161, [GCD 8131 or Biol 4003], Biol 4004, and GCD 4034] or instr consent
MICA 8003 - Immunity and Immunopathology
Credits: 4.0 [max 4.0]
Typically offered: Every Fall
Lymphocyte activation, signal transduction in lymphocytes, antigen receptor genetics, antigen presentation, lymphoid anatomy, adaptive immune responses to microbes, immunodeficiency, immunopathology, cytokines, transplantation, autoimmunity. prereq: Upper level undergrad immunology course or instr consent
MICA 8004 - Cellular and Cancer Biology
Credits: 4.0 [max 4.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Fundamental concepts in cellular, molecular, and genetic basis of disease. Molecular basis of inflammation and cancer metastasis. Genetic basis for inherited disorders and gene therapy. Molecular mechanisms of pathogenesis. prereq: [One undergrad or grad course each in [biochemistry, cell biology]] or instr consent
MICA 8014 - Small RNA Biology
Credits: 2.0 [max 2.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Small RNAs as major regulators of gene/protein expression. MicroRNAs and their potential use in diagnosis/prognosis of various disease conditions, including cancers. Biology of small RNAs and their role in health and disease. prereq: BIOC 8002 or MICA 8004 or equiv or instr consent
MILI 6235 - Pharmaceutical Industry: Business and Policy
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Spring
Business/policy issues specific to pharmaceutical industry. Interdisciplinary perspectives, active involvement by industry leaders.
MILI 6726 - Medical Device Industry: Business and Public Policy
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Fall
This course, with the insight of industry leaders, addresses public-private sector interactions and the business, public policy, regulatory, and technology management issues that concern medical device and biotechnology companies.
MILI 6985 - The Health Care Marketplace
Credits: 2.0 [max 2.0]
Course Equivalencies: MILI 5990/6990/3585/5585
Grading Basis: A-F only
Typically offered: Every Fall & Spring
Survey of trillion dollar medical industry. Physician/hospital services, insurance, pharmaceuticals, medical devices, information technology. Scale, interactions, inter-relationships, market opportunities, barriers. prereq: MBA student
MILI 6995 - Medical Industry Valuation Laboratory
Credits: 2.0 [max 6.0]
Grading Basis: A-F only
Typically offered: Every Fall, Spring & Summer
Interdisciplinary student teams create rapid production market analysis of promising medical technologies/services to determine potential for success in market. Exposure to University innovations, venture firms, inventors. prereq: Grad student
NSC 5461 - Cellular and Molecular Neuroscience
Credits: 3.0 [max 4.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
Lectures by team of faculty, problem sets in important physiological concepts, discussion of original research papers. prereq: NSc grad student or instr consent
NSC 8026 - Neuro-Immune Interactions
Credits: 3.0 [max 3.0]
Course Equivalencies: MVB 8361/NSc 8026/Psy 8026
Typically offered: Periodic Fall & Spring
Regulatory systems (neuroendocrine, cytokine, and autonomic nervous systems) linking brain and immune systems in brain-immune axis. Functional effects of bidirectional brain-immune regulation. Course is offered fall of even-numbered years. prereq: 5561, MicB 4131
NSC 8211 - Developmental Neurobiology
Credits: 2.0 -4.0 [max 4.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
How neuronal types develop. Emphasizes general mechanisms. Experimental data demonstrating mechanisms. prereq: Neuroscience grad student or instr consent
NSCI 5101 - Neurobiology I: Molecules, Cells, and Systems
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall & Spring
This course discusses the basic principles of cellular and molecular neurobiology and nervous systems. The main topics include: Organization of simple networks, neural systems and behavior; how the brain develops and the physiology and communication of neurons and glia; the molecular and genetic basis of cell organization; ion channel structure and function; the molecular basis of synaptic receptors; transduction mechanisms and second messengers; intracellular regulation of calcium; neurotransmitter systems, including excitation and inhibition, neuromodulation, system regulation and the cellular basis of learning, memory and cognition. The course is intended for students majoring in neuroscience, but is open to all students with the required prerequisites.
NSCI 5501 - Neurodegenerative Diseases, Mechanisms to Therapies
Credits: 3.0 [max 3.0]
Course Equivalencies: Nsci 4501/Nsci 5501
Grading Basis: A-F only
Typically offered: Every Fall
With a rapid increase in population aging in western educated industrialized rich democratic (WEIRD) societies, neurodegenerative disorders such as Alzheimer?s disease have become an alarming health priority due to the current absence of disease-modifying therapies. The objective of this course is to acquire a fundamental appreciation for the most common degenerative disorders of the nervous system as well as to integrate central notions shared across these diseases and emerging concepts in the field.
PHCL 5110 - Introduction to Pharmacology
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
This is a course for first-year students in the Graduate Program in Pharmacology. The course introduces students to the basic principles of pharmacology and focuses on molecular mechanisms of drug action. Topics covered include pharmacokinetics, pharmacodynamics, signal transduction, toxicology pharmacogenomics, and drug discovery. Prerequisites: student in the Graduate Program in Pharmacology or approval from the Course Director(s) Keywords: Introduction, Pharmacology, Molecular, Drug, Pharmacokinetics, Pharmacodynamics, Protein, Pharmacokinetics
PHCL 5112 - Foundations of Biomedical Research
Credits: 1.0 -2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Fall
This is a course for first-year students in the Graduate Program of Pharmacology. This course will introduce graduate students to the basic operating principles and techniques of a scientific research laboratory, general concepts surrounding experimental design and experimental controls, and familiarity with common laboratory calculations. Discussion of scientific techniques will include recombinant DNA and molecular biology techniques, protein expression and purification, protein assays, biochemical data analysis and fitting methods, transcriptomics and proteomics studies, and cell culture & mouse models of disease. Methods are presented in the context of highlighting general principles in experimental design. Prerequisites: student in the Graduate Program in Pharmacology Keywords: Basic Science, Pharmacology, Personnel, Writing, Presentation, Protein, DNA, Molecule, Microscope, Bioinformatics, Drug
PHSL 5061 - Principles of Physiology for Biomedical Engineering
Credits: 4.0 [max 4.0]
Typically offered: Every Fall
Human physiology with emphasis on quantitative aspects. Organ systems (circulation, respiration, renal, gastrointestinal, endocrine, muscle, central and peripheral nervous systems), cellular transport processes, and scaling in biology. prereq: Biomedical engineering grad, one yr college chem and physics and math through integral calculus
PHSL 5197 - Stress Physiology
Credits: 1.0 -3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
Journal club format. Meets weekly to examine foundations of stress, historical progress, development of stress, modern stress physiology. Focus on stress-induced pathology with attention to cardiovascular, metabolic, neuroendocrine disorders. Students participating in the weekly discussion are assessed on discussion participation, completion of weekly writing assignments and quality of the presentation in the class, are eligible for 1 credit. Students completing a midterm (test) and a final project (specific aims page of an NIH RO1 grant) in addition to the criteria described above are eligible for 3 credits. Prerequisite: instructor consent is required. Graduate student standing, master students, and post-doctoral fellows (if they are eligible for credits). Undergraduate students must have taken PHSL 3061 or equivalent, and have previous laboratory research experience.
PHSL 5211 - Physiology of Inflammation in Disease
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
In this course, we will explore the latest developments in the field of inflammation-mediated chronic diseases. The students will learn basic concepts of immunity and inflammation and the mechanisms by which non-infectious inflammatory processes mediate chronic disease. Instructor consent is required. Courses in physiology, such as PHSL3051, 3061, and Microbiology and Immunology, such as MICB 4131, are recommended but not required.
PHSL 5221 - Systems and Computational Physiology
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
Physiological processes can involve a complex level of interactions that can be challenging to understand based on intuition alone. Quantitative and computational approaches can be used to help us better understand the mechanisms regulating such complex processes, both in healthy and pathological conditions. In this course, students will be introduced to current methods from systems biology, computational biology, and artificial intelligence to better understand human physiology. We will discuss mathematical approaches to model biological interactions that describe fundamental physiological concepts such as feedback and homeostasis that operate across biological scales, from intracellular enzymes to organ regulation. We will apply these approaches to understand a range of physiological systems, including hormone secretion, circadian rhythms, and inflammation. We will also introduce students to machine learning and deep learning methods, and discuss how these computational approaches are being applied in the areas of clinical physiology and biomedical imaging.
PHSL 5510 - Advanced Cardiac Physiology and Anatomy
Credits: 2.0 -3.0 [max 3.0]
Typically offered: Every Spring
Fundamental concepts, advanced topics related to clinical/biomedical cardiac physiology. Lectures, laboratories, workshops, anatomical dissections. Intense, one week course. prereq: instr consent
PHSL 8242 - Professional Skills Development for Biomedical Scientists
Credits: 2.0 [max 1.0]
Grading Basis: A-F only
Typically offered: Periodic Fall, Spring & Summer
Professional skills development, including critical evaluation of the scientific literature, short oral presentations, development of research project specific aims and grant writing. Students will become familiar with strategies/mechanics of writing a grant proposal, NIH study section grant reviews, scientific presentations, dissecting scientific literature, and PubMed/NIHreporter tools. prereq: instr consent
PSY 5063 - Introduction to Functional MRI
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Fall
How to understand and perform a brain imaging experiment. Theory and practice of functional MRI experimental design, execution, and data analysis. Students develop experimental materials/acquire and analyze their own functional MRI data. Lectures/lab exercises. prereq: Jr or sr or grad or instr consent
PUBH 6450 - Biostatistics I
Credits: 4.0 [max 4.0]
Grading Basis: A-F only
Typically offered: Every Fall & Spring
This course will cover the fundamental concepts of exploratory data analysis and statistical inference for univariate and bivariate data, including: ? study design and sampling methods, ? descriptive and graphical summaries, ? random variables and their distributions, ? interval estimation, ? hypothesis testing, ? relevant nonparametric methods, ? simple regression/correlation, and ? introduction to multiple regression. There will be a focus on analyzing data using statistical programming software and on communicating the results in short reports. Health science examples from the research literature will be used throughout the course. prereq: [College-level algebra, health sciences grad student] or instr consent
PUBH 6451 - Biostatistics II
Credits: 4.0 [max 4.0]
Typically offered: Every Fall & Spring
This course will cover more advanced aspects of statistical analysis methods with a focus on statistical modeling, including: ? two-way ANOVA, ? multiple linear regression, ? logistic regression, ? Poisson regression, ? log binomial and ordinal regression, ? survival analysis methods, including Kaplan-Meier analysis and proportional hazards (Cox) regression, ? power and sample size, and ? survey sampling and analysis. There will be a focus on analyzing data using statistical programming software and on communicating the results in short reports. Health science examples from the research literature will be used throughout the course. prereq: [PubH 6450 with grade of at least B, health sciences grad student] or instr consent