Twin Cities campus

This is archival data. This system was retired as of August 21, 2023 and the information on this page has not been updated since then. For current information, visit catalogs.umn.edu.

 
Twin Cities Campus

Integrative Biology and Physiology M.S.

Integrative Biology and Physiology
Medical School
Link to a list of faculty for this program.
Contact Information
Department of Integrative Biology and Physiology, Jackson Hall 6-125, 321 Church Street S.E., Minneapolis, MN 55455 (612-625-5644)
Email: ibpdept@umn.edu
  • Program Type: Master's
  • Requirements for this program are current for Spring 2023
  • Length of program in credits: 30
  • This program requires summer semesters for timely completion.
  • Degree: Master of Science
Along with the program-specific requirements listed below, please read the General Information section of this website for requirements that apply to all major fields.
Note: The Integrative Biology and Physiology graduate program does not routinely accept applications directly to the MS; rather, the MS is an additional or alternative credential for students admitted to the Integrative Biology and Physiology PhD program. The Twin Cities graduate program has a cardiovascular emphasis, although other areas of specialization are represented. The program includes faculty and corresponding research laboratories from the Department of Integrative Biology and Physiology and also the Departments of Medicine; Surgery; Neuroscience; Neurosurgery; Biochemistry, Molecular Biology, and Biophysics; Pharmacology; Physical Medicine and Rehabilitation; Kinesiology; and Animal Science.
Program Delivery
  • via classroom (the majority of instruction is face-to-face)
Prerequisites for Admission
The preferred undergraduate GPA for admittance to the program is 3.00.
A four-year degree in a basic science discipline is required for admission.
Other requirements to be completed before admission:
Admission to the IBP Masters program requires a four-year degree in a basic science discipline.
Special Application Requirements:
The Department of Biology and Physiology admits students directly into the MS Plan C option only; the MS Plan C plays a critical role in helping students explore advanced physiology-related careers. The MS Plan A or MS Plan B is an additional or alternative credential for students admitted to the Integrative Biology and Physiology PhD program. Under special circumstances, students admitted to the Plan C program may enter the MS Plan A or MS Plan B program.
International applicants must submit score(s) from one of the following tests:
  • TOEFL
    • Internet Based - Total Score: 100
    • Internet Based - Listening Score: 25
    • Internet Based - Writing Score: 25
    • Internet Based - Reading Score: 25
    • Internet Based - Speaking Score: 25
  • IELTS
    • Total Score: 7.0
    • Listening Score: 7.0
    • Reading Score: 7.0
    • Writing Score: 7.0
    • Speaking Score: 7.0
Key to test abbreviations (TOEFL, IELTS).
For an online application or for more information about graduate education admissions, see the General Information section of this website.
Program Requirements
Plan A: Plan A requires 20 major credits, 0 credits outside the major, and 10 thesis credits. The final exam is written and oral.
Plan B: Plan B requires 30 major credits and 0 credits outside the major. The final exam is written and oral. A capstone project is required.
Capstone Project:The Plan B project, completed under the direction of an IBP faculty member, focuses on an aspect of Physiology.
Plan C: Plan C requires 30 major credits and up to credits outside the major. There is no final exam.
This program may be completed with a minor.
Use of 4xxx courses toward program requirements is permitted under certain conditions with adviser approval.
A minimum GPA of 2.80 is required for students to remain in good standing.
At least 2 semesters must be completed before filing a Degree Program Form.
Plan A and Plan B Required Coursework (20 credits)
Plan A and Plan B students take section 002 of PHSL 5061. Take PHSL 8294 at least twice for 2 credits (total 4 credits) PHSL 8242 is offered every other summer. Take PHSL 5096 (seminar) 4 times.
ANSC 5702 - Cell Physiology (4.0 cr)
PHSL 5061 - Principles of Physiology for Biomedical Engineering (4.0 cr)
PHSL 5096 - Integrative Biology and Physiology Research Advances (1.0 cr)
PHSL 8232 - Critical Reading of Journal Articles in Physiology (2.0 cr)
PHSL 8242 - Professional Skills Development for Biomedical Scientists (2.0 cr)
PHSL 8294 - Research in Physiology (1.0-18.0 cr)
Plan C Required Coursework (8 credits)
Take PHSL 5061, sec 001.
PHSL 5061 - Principles of Physiology for Biomedical Engineering (4.0 cr)
PHSL 5702 - Cell Physiology (4.0 cr)
Plan Options
Plan A Thesis Credits
Take at least 10 master's thesis credits.
PHSL 8777 - Thesis Credits: Master's (1.0-18.0 cr)
-OR-
Plan B Coursework
Required Physiology Coursework (6 credits)
Plan B students need to take two of the four courses during Spring semester of year one. If PHSL 5197 is take, choose 3 credit option.
PHSL 5197 - Stress Physiology (1.0-3.0 cr)
PHSL 5211 - Physiology of Inflammation in Disease (3.0 cr)
PHSL 5221 - Systems and Computational Physiology (3.0 cr)
PHSL 5444 - Muscle (3.0 cr)
Biostatistics Requirement (4 credits)
Plan B students select 1 course from the following, in consultation with the director of graduate studies.
PUBH 6414 - Biostatistical Literacy (3.0 cr)
or PUBH 6450 - Biostatistics I (4.0 cr)
or PUBH 6451 - Biostatistics II (4.0 cr)
or STAT 5021 - Statistical Analysis (4.0 cr)
-OR-
Plan C Coursework
Physiology Coursework
Students should choose 4 courses from the following Physiology courses.
PHSL 4021 - Advanced Physiology and Bioengineering: Bionic Human (3.0 cr)
PHSL 4031 - Physiological Discussions: Contemporary Topics (2.0 cr)
PHSL 5115 - Clinical Physiology I (3.0 cr)
PHSL 5116 - Clinical Physiology II (3.0 cr)
PHSL 5211 - Physiology of Inflammation in Disease (3.0 cr)
PHSL 5221 - Systems and Computational Physiology (3.0 cr)
Elective Coursework
Select electives in consultation with the advisor to meet the 30 credit minimum.
BIOC 4331 - Biochemistry I: Structure, Catalysis, and Metabolism in Biological Systems (4.0 cr)
BIOC 4332 - Biochemistry II: Molecular Mechanisms of Signal Transduction and Gene Expression (4.0 cr)
BIOC 6021 - Biochemistry (3.0 cr)
BIOL 4003 - Genetics (3.0 cr)
BIOL 4004 - Cell Biology (3.0 cr)
BIOL 5701 - Science Communication: A Primer for Scientists (2.0 cr)
MICB 4131 - Immunology (3.0 cr)
PHSL 5197 - Stress Physiology (1.0-3.0 cr)
PHSL 5444 - Muscle (3.0 cr)
PHSL 5510 - Advanced Cardiac Physiology and Anatomy (2.0-3.0 cr)
PHSL 5525 - Anatomy and Physiology of the Pelvis and Urinary System (1.0-2.0 cr)
 
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ANSC 5702 - Cell Physiology
Credits: 4.0 [max 4.0]
Course Equivalencies: AnSc 5702/Phsl 4702/Phsl 5702
Grading Basis: A-F only
Typically offered: Every Fall
Cell Physiology involves the study of control mechanisms involved in maintaining homeostasis with respect to a variety of parameters including regulation of pH, volume, nutrient content, intracellular electrolyte composition, membrane potential, receptor signaling and aspects of intercellular communication. The first half of this team-taught course is organized in a partially on-line format where students learn from on-line materials and then take an on-line quiz each week before meeting with the instructor to review key concepts in class. The second half of the course is presented in lecture format. Student evaluation is based on quiz scores, in-class exams and graded problem sets.
PHSL 5061 - Principles of Physiology for Biomedical Engineering
Credits: 4.0 [max 4.0]
Typically offered: Every Fall
Human physiology with emphasis on quantitative aspects. Organ systems (circulation, respiration, renal, gastrointestinal, endocrine, muscle, central and peripheral nervous systems), cellular transport processes, and scaling in biology. prereq: Biomedical engineering grad, one yr college chem and physics and math through integral calculus
PHSL 5096 - Integrative Biology and Physiology Research Advances
Credits: 1.0 [max 4.0]
Grading Basis: A-F only
Typically offered: Every Fall & Spring
Attend/participate in IBP Fall/Spring seminar series. Seminars given by faculty, invited speakers, students. Exposure to key topics. How to present seminars. prereq: instr consent
PHSL 8232 - Critical Reading of Journal Articles in Physiology
Credits: 2.0 [max 4.0]
Grading Basis: A-F only
Typically offered: Every Spring
Integrative physiology, critical reading of current scientific literature related to lecture topics in the Human Physiology course. prereq: concurrent registration is required (or allowed) in PHSL 5101, instr consent
PHSL 8242 - Professional Skills Development for Biomedical Scientists
Credits: 2.0 [max 1.0]
Grading Basis: A-F only
Typically offered: Periodic Fall, Spring & Summer
Professional skills development, including critical evaluation of the scientific literature, short oral presentations, development of research project specific aims and grant writing. Students will become familiar with strategies/mechanics of writing a grant proposal, NIH study section grant reviews, scientific presentations, dissecting scientific literature, and PubMed/NIHreporter tools. prereq: instr consent
PHSL 8294 - Research in Physiology
Credits: 1.0 -18.0 [max 18.0]
Grading Basis: S-N only
Typically offered: Every Fall, Spring & Summer
Directed laboratory research. prereq: Grad cellular and integrative Phsl major, instr consent
PHSL 5061 - Principles of Physiology for Biomedical Engineering
Credits: 4.0 [max 4.0]
Typically offered: Every Fall
Human physiology with emphasis on quantitative aspects. Organ systems (circulation, respiration, renal, gastrointestinal, endocrine, muscle, central and peripheral nervous systems), cellular transport processes, and scaling in biology. prereq: Biomedical engineering grad, one yr college chem and physics and math through integral calculus
PHSL 5702 - Cell Physiology
Credits: 4.0 [max 4.0]
Course Equivalencies: AnSc 5702/Phsl 4702/Phsl 5702
Grading Basis: A-F only
Typically offered: Every Fall
Cell Physiology involves the study of control mechanisms involved in maintaining homeostasis with respect to a variety of parameters including regulation of pH, volume, nutrient content, intracellular electrolyte composition, membrane potential, receptor signaling and aspects of intercellular communication. The first half of this team-taught course is organized in a partially on-line format where students learn from on-line materials and then take an on-line quiz each week before meeting with the instructor to review key concepts in class. The second half of the course is presented in lecture format. Student evaluation is based on quiz scores, in-class exams and graded problem sets. prereq: [Two semesters of physics/chemistry, calculus, one semester of systems-level physiology] or instr consent
PHSL 8777 - Thesis Credits: Master's
Credits: 1.0 -18.0 [max 50.0]
Grading Basis: No Grade
Typically offered: Every Fall, Spring & Summer
(No description) prereq: Max 18 cr per semester or summer; 10 cr total required [Plan A only]
PHSL 5197 - Stress Physiology
Credits: 1.0 -3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
Journal club format. Meets weekly to examine foundations of stress, historical progress, development of stress, modern stress physiology. Focus on stress-induced pathology with attention to cardiovascular, metabolic, neuroendocrine disorders. Students participating in the weekly discussion are assessed on discussion participation, completion of weekly writing assignments and quality of the presentation in the class, are eligible for 1 credit. Students completing a midterm (test) and a final project (specific aims page of an NIH RO1 grant) in addition to the criteria described above are eligible for 3 credits. Prerequisite: instructor consent is required. Graduate student standing, master students, and post-doctoral fellows (if they are eligible for credits). Undergraduate students must have taken PHSL 3061 or equivalent, and have previous laboratory research experience.
PHSL 5211 - Physiology of Inflammation in Disease
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
In this course, we will explore the latest developments in the field of inflammation-mediated chronic diseases. The students will learn basic concepts of immunity and inflammation and the mechanisms by which non-infectious inflammatory processes mediate chronic disease. Instructor consent is required. Courses in physiology, such as PHSL3051, 3061, and Microbiology and Immunology, such as MICB 4131, are recommended but not required.
PHSL 5221 - Systems and Computational Physiology
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
Physiological processes can involve a complex level of interactions that can be challenging to understand based on intuition alone. Quantitative and computational approaches can be used to help us better understand the mechanisms regulating such complex processes, both in healthy and pathological conditions. In this course, students will be introduced to current methods from systems biology, computational biology, and artificial intelligence to better understand human physiology. We will discuss mathematical approaches to model biological interactions that describe fundamental physiological concepts such as feedback and homeostasis that operate across biological scales, from intracellular enzymes to organ regulation. We will apply these approaches to understand a range of physiological systems, including hormone secretion, circadian rhythms, and inflammation. We will also introduce students to machine learning and deep learning methods, and discuss how these computational approaches are being applied in the areas of clinical physiology and biomedical imaging.
PHSL 5444 - Muscle
Credits: 3.0 [max 3.0]
Course Equivalencies: BioC 5444/ Phsl 5444
Typically offered: Every Spring
Muscle molecular structure/function and disease. Muscle regulation, ion transport, and force generation. Muscular dystrophy and heart disease. prereq: PHSL 3061 or PHSL 5061 or BioC 3021, BIOL 3021 or BIOL 4331 or instr consent
PUBH 6414 - Biostatistical Literacy
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Fall, Spring & Summer
Develop ability to read/interpret statistical results in primary literature. Minimal calculation. No formal training in any statistical programming software. Biostatistical Literacy will cover the fundamental concepts of study design, descriptive statistics, hypothesis testing, confidence intervals, odds ratios, relative risks, adjusted models in multiple linear, logistic and Poisson regression, and survival analysis. The focus will be when to use a given method and how to interpret the results, not the actual computation or computer programming to obtain results from raw data. prereq: MPH or certificate student or environmental health or instr consent
PUBH 6450 - Biostatistics I
Credits: 4.0 [max 4.0]
Grading Basis: A-F only
Typically offered: Every Fall & Spring
This course will cover the fundamental concepts of exploratory data analysis and statistical inference for univariate and bivariate data, including: ? study design and sampling methods, ? descriptive and graphical summaries, ? random variables and their distributions, ? interval estimation, ? hypothesis testing, ? relevant nonparametric methods, ? simple regression/correlation, and ? introduction to multiple regression. There will be a focus on analyzing data using statistical programming software and on communicating the results in short reports. Health science examples from the research literature will be used throughout the course. prereq: [College-level algebra, health sciences grad student] or instr consent
PUBH 6451 - Biostatistics II
Credits: 4.0 [max 4.0]
Typically offered: Every Fall & Spring
This course will cover more advanced aspects of statistical analysis methods with a focus on statistical modeling, including: ? two-way ANOVA, ? multiple linear regression, ? logistic regression, ? Poisson regression, ? log binomial and ordinal regression, ? survival analysis methods, including Kaplan-Meier analysis and proportional hazards (Cox) regression, ? power and sample size, and ? survey sampling and analysis. There will be a focus on analyzing data using statistical programming software and on communicating the results in short reports. Health science examples from the research literature will be used throughout the course. prereq: [PubH 6450 with grade of at least B, health sciences grad student] or instr consent
STAT 5021 - Statistical Analysis
Credits: 4.0 [max 4.0]
Typically offered: Every Fall & Spring
Intensive introduction to statistical methods for graduate students needing statistics as a research technique. prereq: college algebra or instr consent; credit will not be granted if credit has been received for STAT 3011
PHSL 4021 - Advanced Physiology and Bioengineering: Bionic Human
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
Is "Iron Man" technology just around the corner? This course will examine how, and if, biomedical devices can address the needs of humans suffering from various pathologies and/or disabilities, or enhance human performance. Advanced discussion of the physiology of organs/organ systems and relevant devices past, present, and future. Emphasis will be on an in-depth understanding of normal physiology including cardiovascular, respiratory, renal, liver, motor, sensory, and pancreatic physiology. Classes will involve review of the physiology of organ systems, design considerations for medical devices, and discussions of published papers about basic science and clinical trials. Classes will be a combination of content presentation and discussion.
PHSL 4031 - Physiological Discussions: Contemporary Topics
Credits: 2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Spring
Students read, critically evaluate, present, and discuss research in cellular and organ system physiology. Journal club setting led by faculty members. prereq: 3061 or 3063 or 5061 or instr consent
PHSL 5115 - Clinical Physiology I
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
Cellular mechanisms, disease states and clinical applications of excitable tissues: cellular transport, neurophysiology, skeletal muscle physiology, cardiovascular physiology. prereq: instr consent
PHSL 5116 - Clinical Physiology II
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Spring
Cellular mechanisms, disease states and clinical applications of metabolic systems: respiratory physiology, renal physiology, acid base physiology, metabolism, gastrointestinal physiology, endocrine physiology, physiology of pregnancy and labor. prereq: instr consent
PHSL 5211 - Physiology of Inflammation in Disease
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
In this course, we will explore the latest developments in the field of inflammation-mediated chronic diseases. The students will learn basic concepts of immunity and inflammation and the mechanisms by which non-infectious inflammatory processes mediate chronic disease. Instructor consent is required. Courses in physiology, such as PHSL3051, 3061, and Microbiology and Immunology, such as MICB 4131, are recommended but not required.
PHSL 5221 - Systems and Computational Physiology
Credits: 3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
Physiological processes can involve a complex level of interactions that can be challenging to understand based on intuition alone. Quantitative and computational approaches can be used to help us better understand the mechanisms regulating such complex processes, both in healthy and pathological conditions. In this course, students will be introduced to current methods from systems biology, computational biology, and artificial intelligence to better understand human physiology. We will discuss mathematical approaches to model biological interactions that describe fundamental physiological concepts such as feedback and homeostasis that operate across biological scales, from intracellular enzymes to organ regulation. We will apply these approaches to understand a range of physiological systems, including hormone secretion, circadian rhythms, and inflammation. We will also introduce students to machine learning and deep learning methods, and discuss how these computational approaches are being applied in the areas of clinical physiology and biomedical imaging.
BIOC 4331 - Biochemistry I: Structure, Catalysis, and Metabolism in Biological Systems
Credits: 4.0 [max 4.0]
Course Equivalencies: BioC 3021/BioC 3022/BioC 4331/
Typically offered: Every Fall & Spring
Advanced survey of structure/catalysis, metabolism/bioenergetics. prereq: (BIOL 1009 or 2003 or equiv) AND (Chem 2302 or CHEM 2081/2085 or equiv)
BIOC 4332 - Biochemistry II: Molecular Mechanisms of Signal Transduction and Gene Expression
Credits: 4.0 [max 4.0]
Typically offered: Every Fall & Spring
Advanced survey of molecular biology. Mechanisms of gene action/biological regulation. prereq: BioC 4331 or Bioc 3201 or BioC 3022
BIOC 6021 - Biochemistry
Credits: 3.0 [max 3.0]
Course Equivalencies: BioC 3021/BioC 3022/BioC 4331/
Typically offered: Every Fall, Spring & Summer
Fundamentals of biochemistry. Structure/function of proteins, nucleic acids, lipids and carbohydrates. Metabolism, regulation of metabolism. Quantitative treatments of chemical equilibria, enzyme catalysis, and bioenergetics. Chemical basis of genetic information flow. prereq: general biology, organic chemistry, instr consent; intended for MBS students
BIOL 4003 - Genetics
Credits: 3.0 [max 3.0]
Course Equivalencies: Biol 4003/GCD 3022
Typically offered: Every Fall, Spring & Summer
Genetic information, its transmission from parents to offspring, its expression in cells/organisms, and its course in populations. prereq: Biol 2003/2003H or BioC 3021 or BioC 4331 or grad
BIOL 4004 - Cell Biology
Credits: 3.0 [max 3.0]
Course Equivalencies: Biol 4004/GCD 3033/4005W
Typically offered: Every Fall, Spring & Summer
Processes fundamental to cells. Emphasizes eukaryotic cells. Assembly/function of membranes/organelles. Cell division, cell form/movement, intercellular communication, transport, secretion pathways. Cancer cells, differentiated cells. prereq: Completion of Biol 4003 is preferred, Biol2003/2003H or Biol4003 or grad
BIOL 5701 - Science Communication: A Primer for Scientists
Credits: 2.0 [max 3.0]
Typically offered: Every Fall, Spring & Summer
Are you interested in honing your skills as a communicator? This class will help you improve your skills and gain confidence through practice and feedback. At the end of the course, you will have two finished pieces that you can use for fellowship applications or to publish. Topics covered include, translating technical concepts and avoiding jargon, understanding your audience and employing storytelling to engage them, identifying what makes science newsworthy, exploring concepts in inclusive science communication, and writing science stories and a three-minute thesis talk. The skills and practice from this course will help you in your future writing, presentations, and networking whether you want a career in academia, industry, nonpro?t, government, or beyond. In addition to gaining a solid foundation in science communication, you will hear from guest speakers and experts about careers translating science.
MICB 4131 - Immunology
Credits: 3.0 [max 3.0]
Course Equivalencies: MicB 4131/VPM 4131
Typically offered: Every Fall
Molecular, genetic and cellular basis for innate and adaptive immune responses. The immune systems role in; transplantation, autoimmune disease, cancer immunotherapy, vaccinololgy, acquired and genetic immunodeficiencies. Prereq: Biol 2003 or Biol 1009 and [Junior or senior]
PHSL 5197 - Stress Physiology
Credits: 1.0 -3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Spring
Journal club format. Meets weekly to examine foundations of stress, historical progress, development of stress, modern stress physiology. Focus on stress-induced pathology with attention to cardiovascular, metabolic, neuroendocrine disorders. Students participating in the weekly discussion are assessed on discussion participation, completion of weekly writing assignments and quality of the presentation in the class, are eligible for 1 credit. Students completing a midterm (test) and a final project (specific aims page of an NIH RO1 grant) in addition to the criteria described above are eligible for 3 credits. Prerequisite: instructor consent is required. Graduate student standing, master students, and post-doctoral fellows (if they are eligible for credits). Undergraduate students must have taken PHSL 3061 or equivalent, and have previous laboratory research experience.
PHSL 5444 - Muscle
Credits: 3.0 [max 3.0]
Course Equivalencies: BioC 5444/ Phsl 5444
Typically offered: Every Spring
Muscle molecular structure/function and disease. Muscle regulation, ion transport, and force generation. Muscular dystrophy and heart disease. prereq: PHSL 3061 or PHSL 5061 or BioC 3021, BIOL 3021 or BIOL 4331 or instr consent
PHSL 5510 - Advanced Cardiac Physiology and Anatomy
Credits: 2.0 -3.0 [max 3.0]
Typically offered: Every Spring
Fundamental concepts, advanced topics related to clinical/biomedical cardiac physiology. Lectures, laboratories, workshops, anatomical dissections. Intense, one week course. prereq: instr consent
PHSL 5525 - Anatomy and Physiology of the Pelvis and Urinary System
Credits: 1.0 -2.0 [max 2.0]
Course Equivalencies: Anat 5525/Phsl 5525
Grading Basis: A-F only
Typically offered: Every Spring
Two-day intensive course. Pelvis, perineum, and urinary system with cadaveric dissection. Structure/function of pelvic and urinary organs, including common dysfunction and pathophysiology. Laboratory dissections, including kidneys, ureters, urinary bladder, pelvic viscera and perineum (male or female), pelvic floor, vascular and nervous structures. Grand rounds section. prereq: One undergrad anatomy course, one undergrad physiology course, instr consent