Twin Cities campus

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Twin Cities Campus

Molecular Pharmacology and Therapeutics PhD

Pharmacology
Medical School
Link to a list of faculty for this program.
Contact Information
6-120 Jackson Hall 321 Church St SE Minneapolis, MN 55104 (612)626-1248
  • Program Type: Doctorate
  • Requirements for this program are current for Spring 2023
  • Length of program in credits: 48
  • This program does not require summer semesters for timely completion.
  • Degree: Doctor of Philosophy
Along with the program-specific requirements listed below, please read the General Information section of this website for requirements that apply to all major fields.
Pharmacology is the study of drugs, the mechanisms through which they affect living systems, and the ways in which drugs are acted upon by living systems. A drug is defined as any foreign entity that exerts an effect on a biological system, whereas a therapeutic is a drug that is intentionally administered in order to elicit a favorable outcome. Investigators in the program in Molecular Pharmacology and Therapeutics (MPaT) focus on developing greater insight into the molecular mechanisms that determine biological responses to therapeutic agents, and how underlying biological variation impacts these responses. In addition, MPaT program faculty strive to develop a greater understanding of basic mechanisms of molecular biology, and in particular how these processes are altered in disease states. The ultimate objective of these latter studies is to gain insight that can lead to the development of future novel therapeutic agents. The MPaT graduate program is designed to prepare students academically and professionally in the field of pharmacological research to make them competent as scientists and competitive as job candidates. Students who have earned their PhD from this program occupy a diverse array of high-level positions in the fields of scientific research, drug development and discovery, and medical outreach.The MPaT graduate program consists of 74 faculty trainers, each of whom is equipped to offer students training in highly diverse research areas. PhD students can expect individualized mentorship and training from their advisors. For their part, students are expected to perform at a high level in the lab and classroom, produce publishable scientific data, and to adhere to the standards established by their advisor, the MPaT graduate program, the Department of Pharmacology, and the University.
Program Delivery
  • via classroom (the majority of instruction is face-to-face)
Prerequisites for Admission
The preferred undergraduate GPA for admittance to the program is 3.50.
A four-year degree in a basic sciences discipline is required for admission
Other requirements to be completed before admission:
Admission to the MPaT program requires a four-year degree (or its equivalent) in a basic sciences discipline, transcripts, three letters of recommendation, a diversity statement, and a statement of career objectives. Applicants whose first language is not English or who have not completed post-secondary education at an approved English-speaking institution are required to demonstrate English-language proficiency by submitting TOEFL or IELTS scores with their application.
International applicants must submit score(s) from one of the following tests:
  • TOEFL
    • Internet Based - Total Score: 100
    • Internet Based - Listening Score: 25
    • Internet Based - Writing Score: 25
    • Internet Based - Reading Score: 25
    • Internet Based - Speaking Score: 25
  • IELTS
    • Total Score: 7.0
    • Listening Score: 7.0
    • Reading Score: 7.0
    • Writing Score: 7.0
    • Speaking Score: 7.0
Key to test abbreviations (TOEFL, IELTS).
For an online application or for more information about graduate education admissions, see the General Information section of this website.
Program Requirements
24 credits are required in the major.
0 credits are required outside the major.
24 thesis credits are required.
This program may be completed with a minor.
Use of 4xxx courses towards program requirements is not permitted.
A minimum GPA of 3.00 is required for students to remain in good standing.
At least 3 semesters must be completed before filing a Degree Program Form.
Students are required to maintain a GPA of 3.00. Students who fail to maintain this standard must petition the director of graduate studies for permission to remain in the program.
Required Courses (24 credits)
Take the following courses. Take PHCL 8100 twice for a total of 8 credits, 2 credits of PHCL 5112, 2 credits of PHCL 8200, and 3 credits of PHCL 8221. All courses, with the exception of PHCL 8100, must be taken A-F and be graded B or higher.
PHCL 5110 - Introduction to Pharmacology (3.0 cr)
PHCL 5112 - Foundations of Biomedical Research (1.0-2.0 cr)
PHCL 8100 - Laboratory Research in Pharmacology (4.0 cr)
PHCL 8200 - SciComm I: Critical Analysis & Publishing (1.0-2.0 cr)
PHCL 8211 - Advanced Pharmacology (5.0 cr)
PHCL 8220 - The Ethical Scientist (1.0 cr)
PHCL 8221 - SciComm II: Writing & Research Presentation (2.0-3.0 cr)
Thesis Credits
Take 24 doctoral thesis credits.
PHCL 8888 - Thesis Credit: Doctoral (1.0-24.0 cr)
 
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· MPaT Sample Plan
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PHCL 5110 - Introduction to Pharmacology
Credits: 3.0 [max 3.0]
Grading Basis: A-F or Aud
Typically offered: Every Fall
This is a course for first-year students in the Graduate Program in Pharmacology. The course introduces students to the basic principles of pharmacology and focuses on molecular mechanisms of drug action. Topics covered include pharmacokinetics, pharmacodynamics, signal transduction, toxicology pharmacogenomics, and drug discovery. Prerequisites: student in the Graduate Program in Pharmacology or approval from the Course Director(s) Keywords: Introduction, Pharmacology, Molecular, Drug, Pharmacokinetics, Pharmacodynamics, Protein, Pharmacokinetics
PHCL 5112 - Foundations of Biomedical Research
Credits: 1.0 -2.0 [max 2.0]
Grading Basis: A-F only
Typically offered: Every Fall
This is a course for first-year students in the Graduate Program of Pharmacology. This course will introduce graduate students to the basic operating principles and techniques of a scientific research laboratory, general concepts surrounding experimental design and experimental controls, and familiarity with common laboratory calculations. Discussion of scientific techniques will include recombinant DNA and molecular biology techniques, protein expression and purification, protein assays, biochemical data analysis and fitting methods, transcriptomics and proteomics studies, and cell culture & mouse models of disease. Methods are presented in the context of highlighting general principles in experimental design. Prerequisites: student in the Graduate Program in Pharmacology Keywords: Basic Science, Pharmacology, Personnel, Writing, Presentation, Protein, DNA, Molecule, Microscope, Bioinformatics, Drug
PHCL 8100 - Laboratory Research in Pharmacology
Credits: 4.0 [max 8.0]
Grading Basis: S-N only
Typically offered: Every Fall & Spring
Supervised independent research in pharmacology. Modern biomedical/pharmacology research methodology, data generation/analysis. Formulation/testing of basic science hypotheses. prereq: Grad student or instr consent Keywords: Pharmacology, Lab, Research, Data, Analysis, Benchwork, Hypothesis, Basic Science
PHCL 8200 - SciComm I: Critical Analysis & Publishing
Credits: 1.0 -2.0 [max 8.0]
Grading Basis: A-F only
Typically offered: Every Fall
The mission of the course is to increase the students? ability to critically evaluate and comprehend the scientific literature, properly present scientific literature/figures, and critique presentations related to the field of pharmacology. After the course is completed, the students will be able to understand and differentiate the six components of a scientific paper, quickly identify the hypothesis and objective of a scientific paper, recognize the key figure(s), with controls, that support the hypothesis, how to present scientific data, how to submit journal articles and navigate the submission and publication process, and critique presentations. Prerequisites: student in the Graduate Program in Pharmacology Keywords: Pharmacology, Seminar, Presentation, Lecture, Research, Basic Science
PHCL 8211 - Advanced Pharmacology
Credits: 5.0 [max 5.0]
Grading Basis: A-F only
Typically offered: Every Spring
This hybrid course offers a combination of online and in-class lectures coupled with interactive literature discussion/flipped classroom components. The course has three sections focusing on 1) pharmacology of the autonomic, cardiovascular, and respiratory systems, 2) anti-cancer and anti-microbial therapeutics and 3) pharmacology of the nervous system. Course Instructors will highlight key features of currently utilized therapeutic agents and underscore recent advances in basic and clinical research that underpin emerging or potential approaches to pharmacotherapy. student in the Graduate Program in Pharmacology, or Course Director consent Keywords: Pharmacology, Drug, Therapy, Medical, Biomedical, Clinic
PHCL 8220 - The Ethical Scientist
Credits: 1.0 [max 1.0]
Grading Basis: S-N only
Typically offered: Every Spring
This course focuses on scientific integrity in research and medicine. Topics to be discussed include best practices for experimental design, data collection, and analysis, regulatory requirements for human and animal studies, collaboration and authorship practices, and other social and ethical issues. Prerequisite: student in the Graduate Program in Pharmacology (GPP), or Course Director consent
PHCL 8221 - SciComm II: Writing & Research Presentation
Credits: 2.0 -3.0 [max 3.0]
Grading Basis: A-F only
Typically offered: Every Fall
In collaboration with their mentors, students will develop thesis projects and scientific communication skills. Specifically, students will learn the principles of oral presentation, hone speaking style and slide content, and prepare for the departmental second-year talk. They will prepare sections of an NIH-style fellowship proposal in time for those eligible to submit an F31 NRSA application for the December deadline. This proposal will also comprise the written component of the preliminary exam. Students will also learn the elements of the closed-door component of the preliminary exam and how best to prepare. Throughout the class, students will provide feedback to their peers, develop critical thinking skills, and practice self-advocacy with their mentors, colleagues, and classmates in soliciting constructive criticism. Prerequisites: student in the Graduate Program in Pharmacology (PhD program) Keywords: Pharmacology, Basic Science, Writing, Presentation, Practice, Thesis, Dissertation
PHCL 8888 - Thesis Credit: Doctoral
Credits: 1.0 -24.0 [max 100.0]
Grading Basis: No Grade
Typically offered: Every Fall, Spring & Summer
(No description) prereq: Max 18 cr per semester or summer; 24 cr required